{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:17:37Z","timestamp":1790399857032,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:00:00Z","timestamp":1525910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["16\u201033\u201060146"],"award-info":[{"award-number":["16\u201033\u201060146"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dentin phosphoprotein (DPP) is a major component of the dentin matrix playing crucial role in hydroxyapatite deposition during bone mineralization, making it a prime candidate for the design of novel materials for bone and tooth regeneration. The bioactivity of DPP\u2010derived proteins is controlled by the phosphorylation and dephosphorylation of the serine residues. Here an enzyme\u2010responsive peptide nanofiber system inducing biomineralization is demonstrated. It closely emulates the structural and functional properties of DPP and facilitates apatite\u2010like mineral deposition. The DPP\u2010mimetic peptide molecules self\u2010assemble through dephosphorylation by alkaline phosphatase (ALP), an enzyme participating in tooth and bone matrix mineralization. Nanofiber network formation is also induced through addition of calcium ions. The gelation process following nanofiber formation produces a mineralized extracellular matrix like material, where scaffold properties and phosphate groups promote mineralization. It is demonstrated that the DPP\u2010mimetic peptide nanofiber networks can be used for apatite\u2010like mineral deposition for bone regeneration.<\/jats:p>","DOI":"10.1002\/mabi.201800080","type":"journal-article","created":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T08:26:57Z","timestamp":1525940817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Dentin Phosphoprotein Mimetic Peptide Nanofibers Promote Biomineralization"],"prefix":"10.1002","volume":"19","author":[{"given":"Gulcihan","family":"Gulseren","sequence":"first","affiliation":[{"name":"Institute of Materials Science and Nanotechnology National Nanotechnology Research Center (UNAM) Bilkent University  Ankara 06800 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulistan","family":"Tansik","sequence":"additional","affiliation":[{"name":"Institute of Materials Science and Nanotechnology National Nanotechnology Research Center (UNAM) Bilkent University  Ankara 06800 Turkey"},{"name":"Department of Biomedical Engineering Department of Pathology DJTMF Biomedical Nanotechnology Institute University of Miami  Coral Gables FL 33136 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruslan","family":"Garifullin","sequence":"additional","affiliation":[{"name":"Institute of Materials Science and Nanotechnology National Nanotechnology Research Center (UNAM) Bilkent University  Ankara 06800 Turkey"},{"name":"Institute of Fundamental Medicine and Biology Kazan Federal University  Kazan 420021 Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse B.","family":"Tekinay","sequence":"additional","affiliation":[{"name":"Institute of Materials Science and Nanotechnology National Nanotechnology Research Center (UNAM) Bilkent University  Ankara 06800 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1168-202X","authenticated-orcid":false,"given":"Mustafa O.","family":"Guler","sequence":"additional","affiliation":[{"name":"Institute for Molecular Engineering University of Chicago  Chicago IL 60637 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,10]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2013.04.003"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.10.028"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6BM00179C"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/cg800252f"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201704476"},{"key":"e_1_2_7_6_1","author":"Eren E. D.","year":"2018","journal-title":"ChemNanoMat"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2017.12.001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00542J"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063187"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.4146"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910208100607"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0909-8836.2004.00110.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20935"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.6A7075.2007"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/84848"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/84728"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303908200"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.08.110"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1349-0079(09)80021-2"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2009.03.006"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413220200"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm2005214"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404279101"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00632a026"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34352"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6TB00795C"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.5b00593"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201300491"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.201700090"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510363109"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02555213"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2006.00347.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0934-8832(11)80215-5"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02555130"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.73"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-001-1011-4"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00661a008"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026534400435"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.2741\/2296"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25102"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80259-7"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v023a02"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411000110030101"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308201003"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008209509016984"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.12.2040"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmabi.201800080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.201800080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T02:12:46Z","timestamp":1694571166000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.201800080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,10]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/mabi.201800080"],"URL":"https:\/\/doi.org\/10.1002\/mabi.201800080","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,10]]},"assertion":[{"value":"2018-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1800080"}}