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However, this approach is often inadequate for large and\/or chronic wounds, which require active intervention via therapeutic cells to promote healing. To address this need, a patch which delivers multipotent adult progenitor cells (MAPCs) is developed. Medical\u2010grade polyurethane (PU) films are modified using plasma immersion ion implantation (PIII), which creates a radical\u2010rich layer capable of rapidly and covalently attaching biomolecules. It is demonstrated that a short treatment duration of 400 s maximizes surface activation and wettability, minimizes reduction in gas permeability, and preserves the hydrolytic resistance of the PU film. The reactivity of PIII\u2010treated PU is utilized to immobilize the extracellular matrix protein tropoelastin in a functional conformation that stably withstands medical\u2010grade ethylene oxide sterilization. The PIII\u2010treated tropoelastin\u2010functionalized patch significantly promotes MAPC adhesion and proliferation over standard PU, while fully maintaining cell phenotype. Topical application of the MAPC\u2010seeded patch transfers cells to a human skin model, while undelivered MAPCs repopulate the patch surface for subsequent cell transfer. The potential of this new wound patch as a reservoir for the sustained delivery of therapeutic MAPCs and cell\u2010secreted factors for large and\/or non\u2010healing wounds is indicated in the findings.<\/jats:p>","DOI":"10.1002\/mabi.201800233","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T16:27:54Z","timestamp":1537892874000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Plasma\u2010Activated Substrate with a Tropoelastin Anchor for the Maintenance and Delivery of Multipotent Adult Progenitor Cells"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6071-8899","authenticated-orcid":false,"given":"Giselle C.","family":"Yeo","sequence":"first","affiliation":[{"name":"Charles Perkins Centre University of Sydney  NSW 2006 Australia"},{"name":"School of Life and Environmental Sciences University of Sydney  NSW 2006 Australia"},{"name":"Bosch Institute University of Sydney  NSW 2006 Australia"},{"name":"The Cooperative Research Centre for Cell Therapy Manufacturing University of South Australia City West Campus  Adelaide SA 5000 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4557-3438","authenticated-orcid":false,"given":"Elena","family":"Kosobrodova","sequence":"additional","affiliation":[{"name":"School of Physics University of Sydney  NSW 2006 Australia"},{"name":"School of Aerospace Mechanical and Mechatronic Engineering University of Sydney  NSW 2006 Australia"},{"name":"The Cooperative Research Centre for Cell Therapy Manufacturing University of South Australia City West Campus  Adelaide SA 5000 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey","family":"Kondyurin","sequence":"additional","affiliation":[{"name":"School of Physics University of Sydney  NSW 2006 Australia"},{"name":"The Cooperative Research Centre for Cell Therapy Manufacturing University of South Australia City West Campus  Adelaide SA 5000 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2476-1301","authenticated-orcid":false,"given":"David R.","family":"McKenzie","sequence":"additional","affiliation":[{"name":"School of Physics University of Sydney  NSW 2006 Australia"},{"name":"The Cooperative Research Centre for Cell Therapy Manufacturing University of South Australia City West Campus  Adelaide SA 5000 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3363-2664","authenticated-orcid":false,"given":"Marcela M.","family":"Bilek","sequence":"additional","affiliation":[{"name":"Charles Perkins Centre University of Sydney  NSW 2006 Australia"},{"name":"School of Physics University of Sydney  NSW 2006 Australia"},{"name":"School of Aerospace Mechanical and Mechatronic Engineering University of Sydney  NSW 2006 Australia"},{"name":"Australian Institute of Nanoscale Science and Technology University of Sydney  NSW 2006 Australia"},{"name":"The Cooperative Research Centre for Cell Therapy Manufacturing University of South Australia City West Campus  Adelaide SA 5000 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony S.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Charles Perkins Centre University of Sydney  NSW 2006 Australia"},{"name":"School of Life and Environmental Sciences University of Sydney  NSW 2006 Australia"},{"name":"Bosch Institute University of Sydney  NSW 2006 Australia"},{"name":"The Cooperative Research Centre for Cell Therapy Manufacturing University of South Australia City West Campus  Adelaide SA 5000 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1053\/spsu.2001.19389"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2006.10.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e31829b0075"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/285869"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.03.033"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02518886"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00666.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000277"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-016-0303-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.06.021"},{"key":"e_1_2_7_12_1","first-page":"2543","volume":"11","author":"Kong Y.","year":"2016","journal-title":"Int. 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