{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:59:01Z","timestamp":1789675141439,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI16C1559"],"award-info":[{"award-number":["HI16C1559"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2016R1D1A1B03931163"],"award-info":[{"award-number":["2016R1D1A1B03931163"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    An innovative technique combining capillary force lithography and phase separation method in one step is applied to fabricate artificial nerve guidance conduit (NGC) for peripheral nerve regeneration. Biodegradable porous, patterned NGC (PP\u2010NGC) using poly(lactic\u2010\n                    <jats:italic>co<\/jats:italic>\n                    \u2010glycolic acid) is fabricated. It has micro\u2010grooves and microporosity on the inner surface to promote axonal outgrowth and to enhance permeability for nutrient exchange. In this study, it is confirmed that the inner surface of micro\u2010grooves can modulate neurite orientation and length of mouse neural stem cell compared to porous flat NGC (PF\u2010NGC) in vitro. Coating with 3,4\u2010dihydroxy\u2010\n                    <jats:sc>l<\/jats:sc>\n                    \u2010phenylalanine (DOPA) facilitates the hydrophilic inner surface of PF\u2010 and PP\u2010NGCs via bioinspired catechol chemistry. For in vivo study, PF\u2010NGC and PP\u2010NGC coated with or without DOPA are implanted in the 10\u00a0mm sciatic nerve defect margins between proximal and distal nerves in rats. Especially, PP\u2010NGC coated with DOPA shows higher sciatic function index score, onset\u2010to\u2010peak amplitude, and muscle fiber diameter compared to other groups. The proposed hybrid\u2010structured NGC not only can serve as a design for functional NGC without growth factor but also can be used in clinical application for peripheral nerve regeneration.\n                  <\/jats:p>","DOI":"10.1002\/mabi.201800290","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T10:31:10Z","timestamp":1541673070000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Biodegradable Nerve Guidance Conduit with Microporous and Micropatterned Poly(lactic\u2010\n                    <i>co<\/i>\n                    \u2010glycolic acid)\u2010Accelerated Sciatic Nerve Regeneration"],"prefix":"10.1002","volume":"18","author":[{"given":"Seong Min","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook University  Cheonan 330\u2013714 Republic of 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