{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:00Z","timestamp":1786978320639,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21474047"],"award-info":[{"award-number":["21474047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51773089"],"award-info":[{"award-number":["51773089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Carbonic anhydrase IX (CA IX), over\u2010expressed on cancer cells, catalyzes CO\n                    <jats:sub>2<\/jats:sub>\n                    to bicarbonate and protons, contributing to the acidic extracellular pH (pHe), which enhances the multidrug resistance of tumor cells. Therefore, alleviating tumor acidosis would greatly improve the outcome of chemotherapy. This work fabricates acetazolamide (ACE)\u2010loaded pH\u2010responsive nanoparticles (ACE\u2010NPs), which are quickly disintegrated in an acidic solution (pH 6.8), resulting in a quick release of ACE from these NPs to inhibit the expression of CA IX, thus up\u2010regulating the pHe value. These ACE\u2010NPs have no obvious in vitro cytotoxicity and in vivo studies confirm the accumulation of ACE\u2010NPs in tumor tissue. In addition, mice treated with ACE and paclitaxel (PTX) co\u2010loaded NPs show a smaller tumor size and a higher survival rate when compared to that of mice treated with ACE\u2010 or PTX\u2010loaded NPs. This work reveals that simultaneous delivery of ACE and chemotherapy agents to tumor tissue can up\u2010regulate the acidic pHe value, consequently enhancing the anti\u2010tumor ability of chemotherapy medicine. These findings open a new window for enhancing the anti\u2010tumor ability of traditional chemotherapy in clinic.\n                  <\/jats:p>","DOI":"10.1002\/mabi.201800366","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T08:14:59Z","timestamp":1543911299000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Acetazolamide\u2010Loaded pH\u2010Responsive Nanoparticles Alleviating Tumor Acidosis to Enhance Chemotherapy Effects"],"prefix":"10.1002","volume":"19","author":[{"given":"Sen","family":"Liu","sequence":"first","affiliation":[{"name":"Shenzhen Research Institute of Nanjing University  Shenzhen 518057 China"},{"name":"College of Engineering and Applied Sciences Nanjing University  Nanjing 210093 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Luo","sequence":"additional","affiliation":[{"name":"Shenzhen Research Institute of Nanjing University  Shenzhen 518057 China"},{"name":"College of Engineering and Applied Sciences Nanjing University  Nanjing 210093 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Shenzhen Research Institute of Nanjing University  Shenzhen 518057 China"},{"name":"College of Engineering and Applied Sciences Nanjing University  Nanjing 210093 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematology Drum Tower Hospital School of Medicine Nanjing University  Nanjing Jiangsu 210093 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianquan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Engineering and Applied Sciences Nanjing University  Nanjing 210093 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Hu","sequence":"additional","affiliation":[{"name":"Shenzhen Research Institute of Nanjing University  Shenzhen 518057 China"},{"name":"College of Engineering and Applied Sciences Nanjing University  Nanjing 210093 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,4]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00625-6"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/13816128113199990493"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.62.070193.002125"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1303888110"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0297-177"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3554"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2008.03.011"},{"key":"e_1_2_7_8_1","first-page":"239","volume":"17","author":"Lotz C.","year":"2007","journal-title":"Oncol. 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