{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:19:08Z","timestamp":1790461148963,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51673145"],"award-info":[{"award-number":["51673145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51873149"],"award-info":[{"award-number":["51873149"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21875157"],"award-info":[{"award-number":["21875157"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31370969"],"award-info":[{"award-number":["31370969"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2013DFG52040"],"award-info":[{"award-number":["2013DFG52040"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Artificial small\u2010caliber vascular grafts are still limited in clinical application because of thrombosis, restenosis, and occlusion. Herein, a small\u2010caliber vascular graft (diameter 2\u00a0mm) is fabricated from poly(\u03b5\u2010caprolactone)\u2010b\u2010poly(isobutyl\u2010morpholine\u20102,5\u2010dione) (PCL\u2010PIBMD) and silk fibroin (SF) by electrospinning technology and then biofunctionalized with low\u2010fouling poly(ethylene glycol) (PEG) and two cell\u2010adhesive peptide sequences (CREDVW and CAGW) with the purpose of enhancing antithrombogenic activity and endothelialization. The successful grafting of PEG and peptide sequences is confirmed by X\u2010ray photoelectron spectroscopy. The suitable surface wettability of the modified vascular graft is testified by water contact angle analysis. The surface hemocompatibility is verified by platelet adhesion assays and protein adsorption assays, and the results demonstrate that both platelet adhesion and protein adsorption on the biofunctionalized surface are significantly reduced. In vitro studies demonstrate that the biofunctionalized surface with suitable hydrophilicity and cell\u2010adhesive peptides can selectively promote the adhesion, spreading, and proliferation of human umbilical vein endothelial cells. More importantly, compared with control groups, this biofunctionalized small\u2010caliber vascular graft shows high long\u2010term patency and endothelialization after 10 weeks of implantation. The biofunctionalization with PEG and two cell\u2010adhesive peptide sequences is an effective method to improve the endothelialization and long\u2010term performance of synthetic vascular grafts.<\/jats:p>","DOI":"10.1002\/mabi.201800386","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T19:21:02Z","timestamp":1543432862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Biofunctionalized Electrospun PCL\u2010PIBMD\/SF Vascular Grafts with PEG and Cell\u2010Adhesive Peptides for Endothelialization"],"prefix":"10.1002","volume":"19","author":[{"given":"Lingchuang","family":"Bai","sequence":"first","affiliation":[{"name":"School of Chemical Engineering and Technology Tianjin University  Yaguan Road 135 Tianjin 300350 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology Tianjin University  Yaguan Road 135 Tianjin 300350 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology Tianjin University  Yaguan Road 135 Tianjin 300350 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintang","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology Tianjin University  Yaguan Road 135 Tianjin 300350 China"},{"name":"Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin)  Tianjin 300350 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangkui","family":"Ren","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology Tianjin University  Yaguan Road 135 Tianjin 300350 China"},{"name":"Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin)  Tianjin 300350 China"},{"name":"Key Laboratory of Systems Bioengineering (Ministry of Education) Tianjin University  Tianjin 300072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihai","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Splenic Medicine Affiliated Hospital Logistics University of People's Armed Police Force  220 Chenglin Road Tianjin 300162 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology Logistics University of Chinese People's Armed Police Force  Tianjin 300309 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4511-0874","authenticated-orcid":false,"given":"Yakai","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology Tianjin University  Yaguan Road 135 Tianjin 300350 China"},{"name":"Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin)  Tianjin 300350 China"},{"name":"Key Laboratory of Systems Bioengineering (Ministry of Education) Tianjin University  Tianjin 300072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"e_1_2_7_1_1","first-page":"5742","volume":"44","author":"Ren X. K.","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"e_1_2_7_2_1","first-page":"350","volume":"20","author":"Wang H. Y.","year":"2012","journal-title":"Macromol. Res."},{"key":"e_1_2_7_3_1","first-page":"549","volume":"21","author":"Tan M. Q.","year":"2013","journal-title":"Macromol. Res."},{"key":"e_1_2_7_4_1","first-page":"869","volume":"21","author":"Wang H. Y.","year":"2013","journal-title":"Macromol. Res."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201300264"},{"key":"e_1_2_7_6_1","first-page":"2315","volume":"32","author":"Wang H. Y.","year":"2012","journal-title":"Mater. Sci. Eng. C"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.34214"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mame.201500038"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.03.032"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reactfunctpolym.2015.04.003"},{"key":"e_1_2_7_11_1","first-page":"7697","volume":"3","author":"Yang J.","year":"2015","journal-title":"J. Mater. Chem. B"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.1574"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm800681k"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.01.039"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.07.002"},{"key":"e_1_2_7_16_1","first-page":"1712","volume":"103","author":"Wang W.","year":"2015","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2006.03.002"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.103.6.2637"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.08.018"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/la0700220"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2012.0577"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.24459"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.07.055"},{"key":"e_1_2_7_24_1","first-page":"1397","volume":"100","author":"Ji Y.","year":"2012","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"e_1_2_7_25_1","first-page":"1173","volume":"136","author":"Wei Y.","year":"2015","journal-title":"Colloids Surf., B"},{"key":"e_1_2_7_26_1","first-page":"2599","volume":"34","author":"Wei Y.","year":"2013","journal-title":"Biomaterials"},{"key":"e_1_2_7_27_1","first-page":"4978","volume":"520","author":"Lin Q. K.","year":"2012","journal-title":"Thin Solid Films"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2011.01.028"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym8030058"},{"key":"e_1_2_7_30_1","first-page":"1377","volume":"26","author":"Yang J.","year":"2015","journal-title":"Polym. Adv. Technol."},{"key":"e_1_2_7_31_1","first-page":"39464","volume":"7","author":"Bai L.","year":"2017","journal-title":"RSC Adv."},{"key":"e_1_2_7_32_1","first-page":"14620","volume":"6","author":"Yang Y.","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.5b00219"},{"key":"e_1_2_7_34_1","first-page":"444","volume":"10","author":"Palmaz J. C.","year":"1999","journal-title":"J. Vasc. Interv. Radiol."},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/2041731417731546"},{"key":"e_1_2_7_36_1","first-page":"5115","volume":"114","author":"Liu Y.","year":"2014","journal-title":"Chem. Rev."},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1148624"},{"key":"e_1_2_7_38_1","first-page":"718","volume":"23","author":"Banerjee I.","year":"2010","journal-title":"Adv. Mater."},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-016-0100-6"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2008.07.006"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201300309"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856206778366059"},{"key":"e_1_2_7_43_1","first-page":"1871","volume":"5","author":"Li D.","year":"2009","journal-title":"Acta Biomater."},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00107a001"},{"key":"e_1_2_7_45_1","first-page":"263","volume":"58","author":"Lin C. C.","year":"2016","journal-title":"Mater. Sci. Eng., C"},{"key":"e_1_2_7_46_1","first-page":"6923","volume":"2","author":"Ge L.","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"e_1_2_7_47_1","first-page":"29288","volume":"8","author":"Yu S.","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"e_1_2_7_48_1","first-page":"11427","volume":"9","author":"Wang K.","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmabi.201800386","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.201800386","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mabi.201800386","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.201800386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T04:33:26Z","timestamp":1694666006000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.201800386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,28]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1002\/mabi.201800386"],"URL":"https:\/\/doi.org\/10.1002\/mabi.201800386","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,28]]},"assertion":[{"value":"2018-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1800386"}}