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Here, the authors report that surface coating of epigallocatechin gallate (EGCG) on polymeric substrates including poly (L\u2010lactic acid) (PLLA) nanofibers can be performed via oxidative polymerization of EGCG in the presence of cations, enabling regulation of biological functions of multiple cell types implicated in bone regeneration. EGCG coating on the PLLA nanofiber promotes osteogenic differentiation of adipose\u2010derived stem cells (ADSCs) and is potent to suppress adipogenesis of ADSCs while significantly reduces osteoclastic maturation of murine macrophages. Moreover, EGCG coating serves as a protective layer for ADSCs against oxidative stress caused by hydrogen peroxide. Finally, the in vivo implantation of EGCG\u2010coated nanofibers into a mouse calvarial defect model significantly promotes the bone regeneration (61.52\u00a0\u00b1\u00a028.10%) as compared to defect (17.48\u00a0\u00b1\u00a011.07%). Collectively, the results suggest that EGCG coating is a simple bioinspired surface modification of polymeric biomaterials and importantly can thus serve as a promising interface for tuning activities of multiple cell types associated with bone fracture healing.<\/jats:p>","DOI":"10.1002\/mabi.201800392","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T19:27:10Z","timestamp":1547580430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Oxidative Epigallocatechin Gallate Coating on Polymeric Substrates for Bone Tissue Regeneration"],"prefix":"10.1002","volume":"19","author":[{"given":"Sajeesh Kumar","family":"Madhurakkat Perikamana","sequence":"first","affiliation":[{"name":"Department of Bioengineering Hanyang University  222 Wangsimni\u2010ro Seongdong\u2010gu Seoul 04763 Republic of Korea"},{"name":"BK21 Plus Future Biopharmaceutical Human Resources Training and Research Team  222 Wangsimni\u2010ro Seongdong\u2010gu Seoul 04763 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Hanyang University  222 Wangsimni\u2010ro Seongdong\u2010gu Seoul 04763 Republic of Korea"},{"name":"BK21 Plus Future Biopharmaceutical Human Resources Training and Research Team  222 Wangsimni\u2010ro Seongdong\u2010gu Seoul 04763 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinkyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Hanyang University  222 Wangsimni\u2010ro Seongdong\u2010gu Seoul 04763 Republic of Korea"},{"name":"BK21 Plus Future Biopharmaceutical Human Resources Training and Research Team  222 Wangsimni\u2010ro Seongdong\u2010gu Seoul 04763 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taufiq","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Hanyang University  222 Wangsimni\u2010ro Seongdong\u2010gu Seoul 04763 Republic of Korea"},{"name":"BK21 Plus Future Biopharmaceutical Human Resources Training and Research Team  222 Wangsimni\u2010ro Seongdong\u2010gu Seoul 04763 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Suk","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nanobiomedical Science &amp; BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook University  Cheonan 31116 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Seok","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nanobiomedical Science &amp; BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook University  Cheonan 31116 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9036-155X","authenticated-orcid":false,"given":"Heungsoo","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Hanyang University  222 Wangsimni\u2010ro Seongdong\u2010gu Seoul 04763 Republic of Korea"},{"name":"BK21 Plus Future Biopharmaceutical Human Resources Training and Research Team  222 Wangsimni\u2010ro Seongdong\u2010gu Seoul 04763 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevBiomedEng.v40.i5.10"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1383(08)70003-2"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2011.03.031"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","unstructured":"A.Schindeler M. 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