{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:48:53Z","timestamp":1783108133563,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T00:00:00Z","timestamp":1584921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006465","name":"Center for Advanced Materials Processing at Clarkson University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006465","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The correlation between erosion and drug (lidocaine and 6\u2010mercaptopurine, 6\u2010MP) release from amorphous poly(thioether anhydrides), which are synthesized using radical\u2010mediated thiol\u2010ene polymerization, is reported. Cytotoxicity studies of the polymer toward human fibroblast human dermal fibroblasts adult, melanoma A\u2010375, and breast cancer MCF\u20107 cells are conducted, and drug efficacy of a cancer and autoimmune disease drug (6\u2010MP) when released from the poly(thioether anhydrides) is examined against two cancerous cell types (A\u2010375 and MCF\u20107). Erosion and drug release studies reveal that lidocaine release is governed by network erosion whereas 6\u2010MP is released by a combination of erosion and diffusion. The cytotoxicity studies show that all three cell types demonstrate high viability, thus cytocompatibility, to poly(thioether anhydrides). Toxicity to the material is dose dependent and comparable to other polyanhydride systems. The 6\u2010MP cancer drug is shown to remain bioactive after encapsulation in the poly(thioether anhydride) matrix and the polymer does not appear to modify the efficacy of the drug.<\/jats:p>","DOI":"10.1002\/mabi.201900377","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T06:34:21Z","timestamp":1585031661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Drug Delivery and Drug Efficacy from Amorphous Poly(thioether anhydrides)"],"prefix":"10.1002","volume":"20","author":[{"given":"Brittany L.","family":"Snyder","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biomolecular Science Clarkson University  Potsdam NY 13699\u20105810 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halimatu S.","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biomolecular Science Clarkson University  Potsdam NY 13699\u20105810 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien S. 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