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To brace health care systems for this considerable risk, alternative therapeutic approaches such as antifungal peptides are urgently needed. In clinical wound care, a significant focus has been directed toward novel surgical (wound) dressings as first defense lines against <jats:italic>C. auris<\/jats:italic>. Inspired by Cerberus the Greek mythological \u201chound of Hades\u201d that prevents the living from entering and the dead from leaving hell, the preparation of a gatekeeper hybrid hydrogel is reported featuring lectin\u2010mediated high\u2010affinity immobilization of <jats:italic>C. auris<\/jats:italic> cells from a collagen gel as a model substratum in combination with a release of an antifungal peptide drug to kill the trapped cells. The vision is an efficient and safe two\u2010layer medical composite hydrogel for the treatment of severe wound infections that typically occur in hospitals. Providing this new armament to the repertoire of possibilities for wound care in critical (intensive care) units may open new routes to shield and defend patients from infections and clinical facilities from spreading and invasion of <jats:italic>C. auris<\/jats:italic> and probably other fungal pathogens.<\/jats:p>","DOI":"10.1002\/mabi.202000005","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T12:27:57Z","timestamp":1582806477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A Cerberus\u2010Inspired Anti\u2010Infective Multicomponent Gatekeeper Hydrogel against Infections with the Emerging \u201cSuperbug\u201d Yeast <i>Candida auris<\/i>"],"prefix":"10.1002","volume":"20","author":[{"given":"Dennis","family":"Kubiczek","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Biotechnology Ulm University  Ulm 89081 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