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Inherent oxidative stress following burn injury is importantly responsible for prolonged inflammation, fibrotic scar, and multiple organ failure. Herein, a bioinspired antioxidative defense system coupling with in situ forming hydrogel, namely, multiresponsive injectable catechol\u2010Fe<jats:sup>3+<\/jats:sup> coordination hydrogel (MICH) matrix, is engineered to promote burn\u2010wound dermal repair by inhibiting tissue oxidative stress. This MICH matrix serves as the special traits of \u201cFe\u2010superoxide dismutases,\u201d small molecular antioxidant (vitamin E), and extracellular matrix (ECM) in alleviating cellular oxidative damage, which demonstrates precise scavenging on reactive oxygen species (ROS) of different cellular locations, blocking lipid peroxidation and cell apoptosis. In in vivo burn\u2010wound treatment, this MICH promptly integrates with injured surrounding tissue to provide hydration microenvironment and physicochemical ECM for burn wounds. Importantly, the MICH matrix suppresses tissue ROS production, reducing the inflammatory response, prompting re\u2010epithelization and neoangiogenesis during wound healing. Meanwhile, the remodeling skin treated with MICH matrix demonstrates low collagen deposition and normal dermal collagen architecture. Overall, the MICH prevents burn wound progression and enhances skin regeneration, which might be a promising biomaterial for burn\u2010wound care and other disease therapy induced by oxidative stress.<\/jats:p>","DOI":"10.1002\/mabi.202000036","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T07:46:30Z","timestamp":1585813590000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Injectable Enzyme\u2010Based Hydrogel Matrix with Precisely Oxidative Stress Defense for Promoting Dermal Repair of Burn Wound"],"prefix":"10.1002","volume":"20","author":[{"given":"Dongmei","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Synthetic and Biological Colloids Ministry of Education School of Chemical and Material Engineering Jiangnan University  Wuxi 214122 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