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However, due its relatively low mechanical properties and water solubility, many inorganic compounds (e.g., bioactive glasses [BGs]) have been used in combination with zein to obtain composite materials with improved mechanical properties. Such inorganic additions provide further biological functionality to zein. In this work, fiber mats of zein with incorporation of BG and copper doped BG particles are successfully obtained by electrospinning. At first the electrospinnability of the blends is assessed, then the morphological and chemical characterization of the mats is done. Degradation study in cell culture medium (Dubelcco\u2019s modified Eagle\u2019s medium) reveals a sufficient strength of the fibers, which in turn is necessary for in vitro cellular studies. Cell culture studies using MG\u201063 and C2C12 cells show promising results, demonstrating increased cell proliferation and growth for fiber mats containing both types of BGs. Also, evaluation with <jats:italic>Staphylococcus aureus<\/jats:italic> and <jats:italic>Escherichia coli<\/jats:italic> bacteria confirms the antibacterial activity of the scaffolds containing copper. The presence of Cu thus imparts antibacterial properties without influencing cell behavior. The developed electrospun fibers represent a novel scaffold system for tissue engineering applications.<\/jats:p>","DOI":"10.1002\/mabi.202000059","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T11:34:24Z","timestamp":1590406464000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Zein\u2010Based Electrospun Fibers Containing Bioactive Glass with Antibacterial Capabilities"],"prefix":"10.1002","volume":"20","author":[{"given":"Camilla E.","family":"Mariotti","sequence":"first","affiliation":[{"name":"Department of Drug Sciences Pharmaceutical and Technology Law Laboratory (PTL) University of Pavia  Viale Taramelli 12 Pavia 27100 Italy"},{"name":"Institute of Biomaterials Department of Materials Science and Engineering University of Erlangen\u2010Nuremberg  Cauerstrasse 6 Erlangen 91058 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9311-6680","authenticated-orcid":false,"given":"Laura","family":"Ramos\u2010Rivera","sequence":"additional","affiliation":[{"name":"Institute of Biomaterials Department of Materials Science and Engineering University of Erlangen\u2010Nuremberg  Cauerstrasse 6 Erlangen 91058 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bice","family":"Conti","sequence":"additional","affiliation":[{"name":"Department of Drug Sciences Pharmaceutical and Technology Law Laboratory (PTL) University of Pavia  Viale Taramelli 12 Pavia 27100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7377-2955","authenticated-orcid":false,"given":"Aldo R.","family":"Boccaccini","sequence":"additional","affiliation":[{"name":"Institute of Biomaterials Department of Materials Science and Engineering University of Erlangen\u2010Nuremberg  Cauerstrasse 6 Erlangen 91058 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,25]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.4248\/BR201303002"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0579-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1383(08)70003-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00121-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/187221008783478608"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma12132079"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2013.03.002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517709464"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4028\/www.scientific.net\/MSF.494.499"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.24619"},{"key":"e_1_2_7_11_1","unstructured":"Federal Register Vol. 50 Office of the Federal Register National Archives and Records Service General Services Administration United States1985 p.8997."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.06.036"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.08.023"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2009.0416"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.01.004"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma3073867"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2011.04.022"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.03.009"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14070813"},{"key":"e_1_2_7_20_1","unstructured":"Committee for Human Medicinal Products Int. 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