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The bilayer P\u2010CA conduit is developed by combining the electrospinning and outer\u2013inner layer methods. Using DSC, as a covalent crosslinker, increases the degradation time of the sodium alginate hydrogel up to 2 months. The swelling ratio of the hydrogel is also 503% during the first 8 h. The DSC cross\u2010linked sodium alginate in the inner layer of the conduit promotes the adhesion and proliferation of nerve cells, while the electrospun PCL nanofibers in the outer layer provide maximum tensile strength of the conduit during surgery. P\u2010CA conduit promotes the migration of Schwann cells along the axon in a rat model based on functional and histological evidences. In conclusion, P\u2010CA conduit will be a promising construct for repairing sciatic nerves in a rat model.<\/jats:p>","DOI":"10.1002\/mabi.202000149","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T10:18:32Z","timestamp":1594030712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Bilayer Cylindrical Conduit Consisting of Electrospun Polycaprolactone Nanofibers and DSC Cross\u2010Linked Sodium Alginate Hydrogel to Bridge Peripheral Nerve Gaps"],"prefix":"10.1002","volume":"20","author":[{"given":"Neshat","family":"Askarzadeh","sequence":"first","affiliation":[{"name":"Faculty of New Sciences and Technologies Department of Life Science Engineering University of Tehran  Tehran 1439957131 Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoumeh Haghbin","family":"Nazarpak","sequence":"additional","affiliation":[{"name":"New Technologies Research Center Amirkabir University of Technology  Tehran 158754413 Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korosh","family":"Mansoori","sequence":"additional","affiliation":[{"name":"Physical medicine and Rehabilitation Neuromusculoskeletal Research Center Iran University of Medical Sciences  Tehran 1449614535 Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Farokhi","sequence":"additional","affiliation":[{"name":"National Cell Bank of Iran Pasteur Institute of Iran  Tehran 1316943551 Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Gholami","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Pharmaceutical Science Research Center Tehran University of Medical Sciences  Tehran 141556451 Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Faculty of New Sciences and Technologies Department of Life Science Engineering University of Tehran  Tehran 1439957131 Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3850-8902","authenticated-orcid":false,"given":"Fatemeh","family":"Mottaghitalab","sequence":"additional","affiliation":[{"name":"Nanotechnology Research Centre Tehran University of Medical Sciences  Tehran 141556451 Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,6]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1080\/09506608.2016.1252551"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074417"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46038"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20161019-01"},{"key":"e_1_2_8_5_1","volume-title":"Electrofluidodynamic Technologies (EFDTs) for Biomaterials and Medical Devices: Principles and Advances","author":"Guarino V.","year":"2018"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/aa6370"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3TB21163K"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.11.020"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.GOX.0000526184.81884.ef"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.1804"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.02.010"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.8b00276"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2017-0389"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/abr.abr_279_16"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34020"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31052"},{"key":"e_1_2_8_17_1","first-page":"4360","volume":"17","author":"Li R.","year":"2018","journal-title":"Mol. 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