{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T08:19:17Z","timestamp":1776586757873,"version":"3.51.2"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["FKZ 03ZZ0910B"],"award-info":[{"award-number":["FKZ 03ZZ0910B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this work ion functionalized hydrogels as potent drug delivery systems are presented. The ion functionalization of the hydrogel enables the retention of ionic drug molecules and thus a reduction of burst release effects. Timolol maleate in combination with polymerized anionic 3\u2010sulfopropylmethacrylate potassium and ibuprofen combined with cationic poly\u2010[2\u2010(methacryloyloxy)ethyl] trimethylammonium chloride are investigated in respect to their drug release profile. The results are showing an ion exchange depending release behavior instead of a diffusion\u2010controlled drug release as it is known from common drug delivery systems. Furthermore, the suitability of such hydrogels for standard methods for sterilization is investigated.<\/jats:p>","DOI":"10.1002\/mabi.202000152","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T11:47:04Z","timestamp":1595245624000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Ion Exchange Controlled Drug Release from Polymerized Ionic Liquids"],"prefix":"10.1002","volume":"20","author":[{"given":"Johanna","family":"Claus","sequence":"first","affiliation":[{"name":"Department of Chemistry Industrial and Applied Chemistry University of Rostock  Albert\u2010Einstein\u2010Str. 3A Rostock 18059 Germany"},{"name":"Department Life, Light and Matter University of Rostock  Albert\u2010Einstein\u2010Stra\u00dfe 25 Rostock 18059 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Eickner","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Engineering Rostock University Medical Center  Friedrich\u2010Barnewitz\u2010Stra\u00dfe 4 Rostock 18119 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Grabow","sequence":"additional","affiliation":[{"name":"Department Life, Light and Matter University of Rostock  Albert\u2010Einstein\u2010Stra\u00dfe 25 Rostock 18059 Germany"},{"name":"Institute for Biomedical Engineering Rostock University Medical Center  Friedrich\u2010Barnewitz\u2010Stra\u00dfe 4 Rostock 18119 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udo","family":"Kragl","sequence":"additional","affiliation":[{"name":"Department of Chemistry Industrial and Applied Chemistry University of Rostock  Albert\u2010Einstein\u2010Str. 3A Rostock 18059 Germany"},{"name":"Department Life, Light and Matter University of Rostock  Albert\u2010Einstein\u2010Stra\u00dfe 25 Rostock 18059 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Oschatz","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Engineering Rostock University Medical Center  Friedrich\u2010Barnewitz\u2010Stra\u00dfe 4 Rostock 18119 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.10.005"},{"key":"e_1_2_8_2_1","first-page":"16","volume":"25","author":"Ullyot G. E.","year":"2000","journal-title":"Bull. Hist. Chem."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(02)00261-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.1356"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30265"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.23613"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b16509"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.06.035"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15954-w"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-chembioeng-073009-100847"},{"key":"e_1_2_8_11_1","volume-title":"Historical Development of Drug Delivery Systems: From Conventional Macroscale to Controlled, Targeted, and Responsive Nanoscale Systems","author":"Abu\u2010Thabit N. Y.","year":"2018"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2013.07.006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ssi.2017.11.012"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2014.940091"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231421"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/15685551.2016.1169380"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.07.006"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.06.011"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2007.02.016"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.06.054"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymertesting.2017.05.034"},{"key":"e_1_2_8_22_1","first-page":"13","volume-title":"Hydrogels","author":"Serrano\u2010Aroca \u00c1.","year":"2018"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2008.01.027"},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1576\/toag.2005.7.3.168","volume":"7","author":"Sutton C.","year":"2005","journal-title":"Obstet. Gynaecol."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA12524J"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328215581507"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2008.01.038"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.0196"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4895173"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmabi.202000152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.202000152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mabi.202000152","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.202000152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T12:53:34Z","timestamp":1693918414000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.202000152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,20]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/mabi.202000152"],"URL":"https:\/\/doi.org\/10.1002\/mabi.202000152","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,20]]},"assertion":[{"value":"2020-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2000152"}}