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How to improve the viability of probiotics in the antibiotics\u2010contaminated environment is of significance. In this study, a new strategy for protecting <jats:italic>Saccharomyces cerevisiae<\/jats:italic> cells in situ against antibiotics is constructed based on cell surface engineering technology by putting on wearable protective layers for cells. The protective layer is constructed around cellular surface via the self\u2010assembly of coacervate microdroplets that consist of carboxymethyl chitosan and carboxyl dextran. Without affecting the cell viability, the protective layer can grasp ciprofloxacin and decrease the contact of ciprofloxacin to cells and consequently improve the survival rate of cells when exposing to ciprofloxacin. This work highlights a facile strategy to establish removable artificial cell wall by biodegradable polysaccharides for improving the productivity of probiotics in antibiotic environments.<\/jats:p>","DOI":"10.1002\/mabi.202000185","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T21:11:37Z","timestamp":1601327497000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A Removable Artificial Cell Wall for Withstanding Ciprofloxacin"],"prefix":"10.1002","volume":"20","author":[{"given":"Hanjiao","family":"Hu","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Guangxi University  Nanning 530004 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingtang","family":"Liang","sequence":"additional","affiliation":[{"name":"Qinzhou Key Laboratory of Biowaste Resources for Selenium\u2010enriched Functional Utilization College of Petroleum and Chemical Engineering Beibu Gulf University  Qinzhou 535011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuangshuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Qinzhou Key Laboratory of Biowaste Resources for Selenium\u2010enriched Functional Utilization College of Petroleum and Chemical Engineering Beibu Gulf University  Qinzhou 535011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijun","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Harbin Institute of Technology  Harbin 150001 P. 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