{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:48:29Z","timestamp":1765961309497,"version":"3.41.2"},"reference-count":86,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The synthesis of a novel and attractive class of nonsteroidal anti\u2010inflammatory and antimicrobial organoiron dendrimers attached to the well\u2010known drug ibuprofen is achieved. The structures of these dendrimers are established by spectroscopic and analytical techniques. The antimicrobial activity of these dendrimers is investigated and tested against five human pathogenic Gram\u2010positive and Gram\u2010negative bacteria, and minimum inhibitory concentrations are reported. Some of these synthesized dendrimers exhibit higher inhibitory activity against methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic>, vancomycin\u2010resistant <jats:italic>Enterococcus faecium<\/jats:italic>, and\u00a0<jats:italic>Staphylococcus warneri<\/jats:italic>\u00a0compare to the reference drugs. As well, the in vitro and in vivo anti\u2010inflammatory activities of these dendrimers are evaluated. The results of in vivo anti\u2010inflammatory activity and histopathology of inflamed paws show that all dendrimers display considerable anti\u2010inflammatory activity; however, second\u2010generation dendrimer\u00a0(<jats:bold>G2\u2010D6<\/jats:bold>)\u00a0shows the best anti\u2010inflammatory activity, which is more potent than the commercial drug ibuprofen at the same tested dose. Results of the toxicity study reveal that <jats:bold>G2\u2010D6<\/jats:bold>\u00a0is the safest drug on biological tissues.<\/jats:p>","DOI":"10.1002\/mabi.202000242","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T05:50:37Z","timestamp":1602827437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Pharmacological Evaluation of Novel Organoiron Dendrimers as Antimicrobial and Anti\u2010Inflammatory Agents"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2808-1151","authenticated-orcid":false,"given":"Alaa S.","family":"Abd\u2010El\u2010Aziz","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Prince Edward Island 550 University Avenue  Charlottetown PE C1A 4P3 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amani A.","family":"Abdelghani","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Prince Edward Island 550 University Avenue  Charlottetown PE C1A 4P3 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebtehal G.","family":"El\u2010Ghezlani","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Prince Edward Island 550 University Avenue  Charlottetown PE C1A 4P3 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doaa","family":"Abou El\u2010ezz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy October University for Modern Sciences and Arts (MSA University)  Giza 12566 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila H.","family":"Abdel\u2010Rahman","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science Sohag University  Sohag 82524 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,15]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22101581"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201800711"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10904-019-01293-y"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20010105)40:1<74::AID-ANIE74>3.0.CO;2-C"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1295\/polymj.17.117"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00211a052"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/cm00056a006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.20000"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2005.10.032"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-3057(03)00100-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2005.09.014"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1367-5931(02)00347-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2005.09.014"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1171"},{"key":"e_1_2_8_14_1","first-page":"365","volume":"25","author":"Yi E.\u2010Y.","year":"2004","journal-title":"Int. J. Oncol."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.02.012"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-013-0757-3"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/macp.201500489"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2016.04.002"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1984-82502013000700006"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2741\/2774"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2217\/17435889.3.5.679"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0608371"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2174\/157489106778777583"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-8545(99)00036-3"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2016.06.032"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00512a071"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1304"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/b903188j"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2012.08.024"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-8545(02)00032-2"},{"key":"e_1_2_8_31_1","first-page":"305","volume":"16","author":"Astruc D.","year":"1992","journal-title":"New J. Chem."},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma051645s"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10904-010-9393-2"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.5b01207"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6PY00443A"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10904-017-0768-5"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.12.002"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10904-005-7876-3"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano7070163"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2011.05.041"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.03.023"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2016.06.009"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.6b00420"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins9090274"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S175212"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.01.045"},{"key":"e_1_2_8_47_1","first-page":"1039","volume":"164","author":"Stienburg K. L.","year":"2001","journal-title":"Can. Med. Assoc. J."},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/673131"},{"key":"e_1_2_8_49_1","first-page":"177","volume":"75","author":"Dall L.","year":"2005","journal-title":"Cutis"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.07.003"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1159\/000277599"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00781"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9603-6"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2809"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2001.396"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-1696"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.11.051"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-002-0485-8"},{"key":"e_1_2_8_59_1","first-page":"4629","volume":"60","author":"Attiga F. A.","year":"2000","journal-title":"Cancer Res."},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.6b00415"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21079"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/pola.1249"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.197805221"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1080\/21501203.2014.931893"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00284a003"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-5457-4_37"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-2052-5"},{"key":"e_1_2_8_68_1","first-page":"177","volume":"1","author":"Binny K.","year":"2010","journal-title":"J.\u00a0Basic\u00a0Clin.\u00a0Pharm."},{"volume-title":"Bancroft's Theory and Practice of Histological Techniques","year":"2019","author":"Suvarna K. S.","key":"e_1_2_8_69_1"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072365"},{"volume-title":"Theory and practice of histological techniques","year":"1996","author":"Bancroft J. D.","key":"e_1_2_8_71_1"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15102321"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1515\/znc-1999-3-405"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1006\/jtbi.2000.2062"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/np070446u"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8PP00192H"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb4000844"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12322"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1159\/000136357"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0003OC"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA16613F"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.22270\/jddt.v6i2.1195"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2014.05.001"},{"volume-title":"Principles and Methods of Toxicology","year":"1982","author":"Plaa G. L.","key":"e_1_2_8_84_1"},{"key":"e_1_2_8_85_1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.5858\/134.4.532","volume":"134","author":"\u015een S.","year":"2010","journal-title":"Arch. Pathol. Lab. Med."}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.202000242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mabi.202000242","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.202000242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T16:19:01Z","timestamp":1693757941000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.202000242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,15]]},"references-count":86,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/mabi.202000242"],"URL":"https:\/\/doi.org\/10.1002\/mabi.202000242","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"type":"print","value":"1616-5187"},{"type":"electronic","value":"1616-5195"}],"subject":[],"published":{"date-parts":[[2020,10,15]]},"assertion":[{"value":"2020-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2000242"}}