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Therefore, BAIs are a serious concern that must be urgently resolved. Materials with antibacterial properties have become hotspots of current research and development. In the present work, quaternized chitosan (QCS) is used as an antibacterial agent and blended with thermoplastic polyurethane (TPU) to create an antibacterial material for tracheal intubation tubes. The modified TPU material (QCS\u2010TPU) exhibited good mechanical properties and excellent long\u2010term antibacterial performance. Under in vitro hydrodynamic conditions, QCS\u2010TPU retained its strong antibacterial properties. QCS\u2010TPU also possessed a low hemolysis rate and cytotoxicity. The current work is expected to provide a facile and feasible strategy for the preparation of antibacterial catheters and aid in the discovery of promising clinical applications to prevent BAIs.<\/jats:p>","DOI":"10.1002\/mabi.202000318","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T09:51:10Z","timestamp":1606902670000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Bulk Modification of Thermoplastic Polyurethanes for Self\u2010Sterilization of Trachea Intubation"],"prefix":"10.1002","volume":"21","author":[{"given":"Yifan","family":"Guo","sequence":"first","affiliation":[{"name":"Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology) Ministry of Education Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongfa","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology) Ministry of Education Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Duan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology) Ministry of Education Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2201-2208","authenticated-orcid":false,"given":"Xiaokang","family":"Ding","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology) Ministry of Education Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology) Ministry of Education Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejia","family":"Ding","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology) Ministry of Education Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1838-8811","authenticated-orcid":false,"given":"Fu\u2010Jian","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology) Ministry of Education Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,2]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2019.02.002"},{"key":"e_1_2_7_2_1","first-page":"678","volume":"58","author":"Kuci\u00f1ska\u2010Lipkab J.","year":"2013","journal-title":"Polymer"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1076\/apab.106.2.100.4384"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3233\/BME-2012-0726"},{"key":"e_1_2_7_5_1","first-page":"1479","volume":"4","author":"Kim S.","year":"2018","journal-title":"ACS Biomater. 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