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As ionizing irradiation can affect the physicochemical properties of PMMA, understanding the consequences of E\u2010beam sterilization on the intrinsic properties of PMMA is vital for clinical implementation. A detailed assessment of the chemical, optical, mechanical, morphological, and biological properties of medical\u2010grade PMMA after E\u2010beam sterilization at 25 and 50 kiloGray (kGy) is reported. Fourier transform infrared spectroscopy, thermogravimetric analysis, and differential scanning calorimetry studies indicate that E\u2010beam irradiation has minimal effect on the chemical properties of the PMMA at these doses. While 25 kGy irradiation does not alter the mechanical and optical properties of the PMMA, 50 kGy reduces the flexural strength and transparency by 10% and 2%, respectively. Atomic force microscopy demonstrates that E\u2010beam irradiation reduces the surface roughness of PMMA in a dose dependent manner. Live\u2010Dead, AlamarBlue, immunocytochemistry, and complement activation studies show that E\u2010beam irradiation up to 50 kGy has no adverse effect on the biocompatibility of the PMMA. These findings suggest that E\u2010beam irradiation at 25 kGy may be a safe and efficient alternative for PMMA sterilization.<\/jats:p>","DOI":"10.1002\/mabi.202000379","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T06:30:29Z","timestamp":1614148229000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Electron Beam Sterilization of Poly(Methyl Methacrylate)\u2014Physicochemical and Biological Aspects"],"prefix":"10.1002","volume":"21","author":[{"given":"Sina","family":"Sharifi","sequence":"first","affiliation":[{"name":"Disruptive Technology Laboratory Massachusetts Eye and Ear and Schepens Eye Research Institute Department of Ophthalmology Harvard Medical School Boston MA 02114 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mirazul","family":"Islam","sequence":"additional","affiliation":[{"name":"Disruptive Technology Laboratory Massachusetts Eye and Ear and Schepens Eye Research Institute Department of Ophthalmology Harvard Medical School Boston MA 02114 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Sharifi","sequence":"additional","affiliation":[{"name":"Disruptive Technology Laboratory Massachusetts Eye and Ear and Schepens Eye Research Institute Department of Ophthalmology Harvard Medical School Boston MA 02114 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakibul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Immunology Oslo University Hospital Rikshospitalet University of Oslo Oslo 0424 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahmida N.","family":"Huq","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Metallurgy University of Cambridge Cambridge CB3 0FS UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per H.","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Immunology Oslo University Hospital Rikshospitalet University of Oslo Oslo 0424 Norway"},{"name":"Linnaeus Center for Biomaterials Chemistry Linnaeus University Kalmar 45027 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom E.","family":"Mollnes","sequence":"additional","affiliation":[{"name":"Department of Immunology Oslo University Hospital Rikshospitalet University of Oslo Oslo 0424 Norway"},{"name":"Research Laboratory, Nordland Hospital, Bod\u00f8, and Faculty of Health Sciences, K.G. Jebsen TREC University of Troms\u00f8 Troms\u00f8 9019 Norway"},{"name":"Centre of Molecular Inflammation Research Norwegian University of Science and Technology Trondheim 7491 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khoa D.","family":"Tran","sequence":"additional","affiliation":[{"name":"Vision Research Laboratory Lions VisionGift Portland OR 97214 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrina","family":"Patzer","sequence":"additional","affiliation":[{"name":"Vision Research Laboratory Lions VisionGift Portland OR 97214 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claes H.","family":"Dohlman","sequence":"additional","affiliation":[{"name":"Disruptive Technology Laboratory Massachusetts Eye and Ear and Schepens Eye Research Institute Department of Ophthalmology Harvard Medical School Boston MA 02114 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirak K.","family":"Patra","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Biotechnology Cambridge University Cambridge CB3 0AS UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftherios I.","family":"Paschalis","sequence":"additional","affiliation":[{"name":"Disruptive Technology Laboratory Massachusetts Eye and Ear and Schepens Eye Research Institute Department of Ophthalmology Harvard Medical School Boston MA 02114 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Gonzalez\u2010Andrades","sequence":"additional","affiliation":[{"name":"Disruptive Technology Laboratory Massachusetts Eye and Ear and Schepens Eye Research Institute Department of Ophthalmology Harvard Medical School Boston MA 02114 USA"},{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC) Department of Ophthalmology Reina Sofia University Hospital and University of Cordoba Cordoba 14004 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7463-1599","authenticated-orcid":false,"given":"James","family":"Chodosh","sequence":"additional","affiliation":[{"name":"Disruptive Technology Laboratory Massachusetts Eye and Ear and Schepens Eye Research Institute Department of Ophthalmology Harvard Medical School Boston MA 02114 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,24]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radphyschem.2007.02.068"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-806X(01)00664-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4557-7881-2.00002-X"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-583X(88)90191-7"},{"key":"e_1_2_8_4_1","volume-title":"Biomaterials, Artificial organs and Tissue Engineering","author":"Hill R. 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