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However, physical interaction of implant with tissue and hydroxyapatite coating suffers from slow implant tissue integration and lack of long\u2010term stability. In this study, a novel poly(phthalazinone ether sulfone ketone) containing allyl groups (APPBAESK) is coated onto PPBESK sheet for reacting with the allyl groups of the hydrogel coating to enhance its stability. N\u2010Succinimidyl (NHS)\u2010ester activated group and nano\u2010hydroxyapatite (nano\u2010HA) are introduced into the hydrogel synthesized from gelatin methacrylate (GelMA) and acrylic acid to construct a nanocomposite hydrogel coating on PPBESK which is a promising PAEK implant material. The hydrophilicity of the PPBESK sheet is improved by the hydrogel coating. The chemical components of the nanocomposite hydrogel coating are confirmed by X\u2010ray photoelectron spectroscope, Attenuated total reflection infrared, and X\u2010ray powder diffraction. The tissue shear adhesion strength of the hydrogel coating toward pig skin is enhanced due to the synergism of NHS\u2010ester activated group and nano\u2010HA. The osteogenic differentiation of MC3T3\u2010E1 preosteoblasts is promoted by nano\u2010HA in nanocomposite hydrogel coating. Therefore, the bifunctional nanocomposite hydrogel coating provides a great application prospect in the surface modification of PAEK implants in bone tissue engineering.<\/jats:p>","DOI":"10.1002\/mabi.202100078","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T12:35:00Z","timestamp":1624106100000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Enhancing Tissue Adhesion and Osteoblastic Differentiation of MC3T3\u2010E1 Cells on Poly(aryl ether ketone) by Chemically Anchored Hydroxyapatite Nanocomposite Hydrogel Coating"],"prefix":"10.1002","volume":"21","author":[{"given":"Chengde","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Liaoning High Performance Resin Engineering Research Center Department of Polymer Science and Engineering Dalian University of Technology  Dalian 116024 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Pan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Liaoning High Performance Resin Engineering Research Center Department of Polymer Science and Engineering Dalian University of Technology  Dalian 116024 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Liaoning High Performance Resin Engineering Research Center Department of Polymer Science and Engineering Dalian University of Technology  Dalian 116024 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wentao","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Liaoning High Performance Resin Engineering Research Center Department of Polymer Science and Engineering Dalian University of Technology  Dalian 116024 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizheng","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Liaoning High Performance Resin Engineering Research Center Department of Polymer Science and Engineering Dalian University of Technology  Dalian 116024 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xitong","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Liaoning High Performance Resin Engineering Research Center Department of Polymer Science and Engineering Dalian University of Technology  Dalian 116024 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2061-2907","authenticated-orcid":false,"given":"Xigao","family":"Jian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Liaoning High Performance Resin Engineering Research Center Department of Polymer Science and Engineering Dalian University of Technology  Dalian 116024 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,19]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.12.001"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.10.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.07.013"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2006.11.005"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(01)00300-3"},{"key":"e_1_2_8_6_1","first-page":"37","volume":"1","author":"Liu Y.","year":"1999","journal-title":"Acta Polym. 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