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They continue to remain a challenge in the clinic particularly in the vision system. For example, infectious endophthalmitis is a major blind\u2010causing disease caused by bacteria. A highly efficient synergistic antibacterial treatment that uses a photothermal antibacterial therapeutic with a chemo\u2010antibacterial therapeutic in a multifunctional nanocomposite is reported. It is prepared by immobilizing vancomycin onto the surface of a magnetic chitosan\u2010graphene (VCM\u2010MCG) composite. An antibacterial effect is achieved when VCM\u2010MCG is applied. This effect is enhanced when the nanocomposites are irradiated with a near\u2010infrared laser. Growth of gram\u2010positive methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> and gram\u2010negative <jats:italic>Escherichia coli<\/jats:italic> bacteria are suppressed efficiently. 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