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In this work, polyglycerol functionalized MoS<jats:sub>2<\/jats:sub> nanosheets with photothermal and pH dual\u2010stimuli responsive properties are used for the co\u2010delivery of doxorubicin and chloroquine and treatment of multidrug\u2010resistant HeLa (HeLa\u2010R) cells. The polyglycerol functionalized MoS<jats:sub>2<\/jats:sub> nanosheets with 80\u00a0nm average size show a high biocompatibility and loading efficiency (\u224890%) for both drugs. The release of drugs from the nanosheets at pH 5.5 is significantly promoted by laser irradiation leading to efficient destruction of incubated HeLa\u2010R cells. In vitro evaluation shows that the designed nanoplatform has a high ability to kill HeLa\u2010R cells. Confocal experiments demonstrate that the synthesized drug delivery system enhances the cellular uptake of DOX via folic acid targeting ligand. Taking advantage of the combined properties including biocompatibility and targeting ability as well as high loading capacity and photothermal release, this multifunctional nanosystem is a promising candidate for anticancer therapy.<\/jats:p>","DOI":"10.1002\/mabi.202100233","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T18:46:52Z","timestamp":1629398812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Co\u2010Delivery of Doxorubicin and Chloroquine by Polyglycerol Functionalized MoS2 Nanosheets for Efficient Multidrug\u2010Resistant Cancer Therapy"],"prefix":"10.1002","volume":"21","author":[{"given":"Shaohui","family":"Xu","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Chemie und Biochemie Freie Universit\u00e4t Berlin  Takustr. 3 Berlin 14195 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