{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:49Z","timestamp":1786978189358,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51903243"],"award-info":[{"award-number":["51903243"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020QH359"],"award-info":[{"award-number":["ZR2020QH359"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The possibility of using drug loaded bovine serum albumin (BSA) porous films as therapeutic contact lenses is investigated. Kaempferol (KAE), a hydrophobic antioxidant and anti\u2010inflammatory agent, is incorporated into BSA porous films to form BSA\/KAE films. The BSA\/KAE films are transparent in the visible wavelength range of the human eye, possessing high water content and good cytocompatibility. A prolonged and sustained drug release is observed, and the in vivo efficacy of BSA\/KAE films is better than the individual KAE. BSA\/KAE films promoted the corneal re\u2010epithelialization, inhibited neovascularization, and reduced the inflammation of an alkali burn induced corneal injury model. The study demonstrates the promising potential of BSA\/KAE films as therapeutic contact lenses for the treatment of corneal injury, builds an available ocular drug delivery platform for ocular diseases.<\/jats:p>","DOI":"10.1002\/mabi.202100269","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T03:40:20Z","timestamp":1631763620000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Kaempferol Incorporated Bovine Serum Albumin Fibrous Films for Ocular Drug Delivery"],"prefix":"10.1002","volume":"21","author":[{"given":"Chuanjin","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Pharmacy Collegeof Chemical Engineering Qingdao University of Science and Technology Zhengzhou Road 53 Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University Daxue Road 269 Xuzhou 221100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueju","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Collegeof Chemical Engineering Qingdao University of Science and Technology Zhengzhou Road 53 Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanlong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Collegeof Chemical Engineering Qingdao University of Science and Technology Zhengzhou Road 53 Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4555-2688","authenticated-orcid":false,"given":"Xiaochen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Collegeof Chemical Engineering Qingdao University of Science and Technology Zhengzhou Road 53 Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,16]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/196827"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001671"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-015-3042-y"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2016.04.016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119133"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.10.006"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.11.053"},{"key":"e_1_2_8_8_1","first-page":"12248","volume":"7","author":"Xu S.","year":"2019","journal-title":"ACS Sustainable Chem. 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