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In clinical applications, complications can lead to increased mortality and morbidity rates. In this work, a biomimetic erythrocyte membrane zwitterion coating based on poly(2\u2010methacryloyloxyethyl phosphorylcholine\u2010<jats:italic>co<\/jats:italic>\u2010dopamine methacrylate) (pMPCDA) copolymers is uniformly and robustly modified onto a polyvinyl chloride (PVC) catheter via mussel\u2010inspired surface chemistry. The zwitterionic pMPCDA coating exhibits excellent antifouling activity and resists bacterial adhesion, fibrinogen adsorption, and platelet adhesion\/activation. The material also demonstrates great hemocompatibility, cytocompatibility, and anticoagulation properties in vitro. Additionally, this biocompatible pMPCDA coating reduces in vivo foreign\u2010body reactions by mitigating inflammatory response and collagen capsule formation, due to its outstanding ability to resist nonspecific protein adsorption. More importantly, when compared with a bare PVC catheter, the pMPCDA coating exhibits outstanding antithrombotic properties when tested in an ex vivo rabbit perfusion model. Thus, it is envisioned that this biomimetic erythrocyte membrane surface strategy will provide a promising way to mitigate inflammation and thrombosis caused by the use of blood\u2010contacting catheters.<\/jats:p>","DOI":"10.1002\/mabi.202100341","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T23:55:58Z","timestamp":1634255758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["A Uniform and Robust Bioinspired Zwitterion Coating for Use in Blood\u2010Contacting Catheters with Improved Anti\u2010Inflammatory and Antithrombotic Properties"],"prefix":"10.1002","volume":"21","author":[{"given":"Yuqi","family":"Liu","sequence":"first","affiliation":[{"name":"Collage of Biomass Chemistry and Engineering Sichuan University  Chengdu 610065 China"},{"name":"National Engineering Research Center of Clean Technology in Leather Industry Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials Sichuan University  Chengdu 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiying","family":"Lang","sequence":"additional","affiliation":[{"name":"Collage of Biomass Chemistry and Engineering Sichuan University  Chengdu 610065 China"},{"name":"National Engineering Research Center of Clean Technology in Leather Industry Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials Sichuan University  Chengdu 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Gao","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials Sichuan University  Chengdu 610064 China"},{"name":"Chengdu Daxan Innovative Medical Tech. 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