{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:35:27Z","timestamp":1790951727273,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Artificial nerve guidance conduits (NGCs) can be potentially used to address the problems of peripheral nerve defects. The biomaterial polyurethane (PU) has already been used to construct NGCs. However, the use of a combination of PU\u2010based NGCs and other bioactive cues, such as extracellular matrix proteins and growth factors, has not been reported yet. A PU conduit grafted with a vascular endothelial growth factor (VEGF)\u2010loaded hydrogel (abbreviated as PU\/Gel\/VEGF conduit) is fabricated. The leachate generated during the use of the PU\/Gel\/VEGF conduit could facilitate the proliferation, migration, and expression of the neural marker S100<jats:italic>\u03b2<\/jats:italic> in RSC96 cells (in vitro). The walking track and target muscle are analyzed, and it is observed that PU\/Gel\/VEGF conduits promote the functional recovery of the injured side. Various histological staining analyses are carried out, and the results reveal that the PU\/Gel\/VEGF conduit effectively improves the extent of nerve regeneration achieved. The number of blood vessels developed during the regeneration of the axons in the PU\/Gel\/VEGF group (attributable to the pro\u2010angiogenic effect of the functional NGC) is higher than the number of blood vessels developed in the PU\/Gel conduit. Overall, the results indicate that PU\/Gel\/VEGF conduits could promote the process of peripheral nerve regeneration.<\/jats:p>","DOI":"10.1002\/mabi.202100397","type":"journal-article","created":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T18:39:00Z","timestamp":1638643140000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Biocompatible Polyurethane Conduit Grafted with Vascular Endothelial Growth Factor\u2010Loaded Hydrogel Repairs the Peripheral Nerve Defect in Rats"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3291-8153","authenticated-orcid":false,"given":"Wanlin","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial\u2010Head and Neck Oncology Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine College of Stomatology Shanghai Jiao Tong University National Center for Stomatology National 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