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Here, patient\u2010specific composite bioimplants, consisting of cross\u2010linked poly(trimethylene carbonate) (PTMC) networks and <jats:italic>\u03b2<\/jats:italic>\u2010tricalcium phosphate (<jats:italic>\u03b2<\/jats:italic>\u2010TCP), are tested in vivo in twelve G\u00f6ttingen minipigs in a large mandibular continuity defect model. The 25\u00a0mm defects are supported by patient\u2010specific titanium reconstruction plates and receive either osteoconductive composite bioimplants (PTMC+TCP), neat polymer network bioimplants (PTMC), autologous bone segments (positive control), or are left empty (negative control). Postoperatively, defects treated with bioimplants show evident ossification at 24 weeks. Histopathologic evaluation reveals that neat PTMC bioimplant surfaces are largely covered with fibrous tissue, while in the PTMC+TCP bioimplants, bone attached directly to the implant surface shows good osteoconduction and histological signs of osteoinductivity. However, PTMC+TCP bioimplants are associated with high incidence of necrosis and infection, possibly due to rapid resorption and\/or particle size of the used <jats:italic>\u03b2<\/jats:italic>\u2010TCP. The study highlights the importance of testing bone regeneration implants in a clinically relevant large animal model and at the in situ reconstruction site, since results on small animal models and studies in nonloadbearing areas do not translate directly.<\/jats:p>","DOI":"10.1002\/mabi.202100398","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T09:21:51Z","timestamp":1642065711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Patient\u2010Specific Bioimplants and Reconstruction Plates for Mandibular Defects: Production Workflow and In Vivo Large Animal Model Study"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4983-3102","authenticated-orcid":false,"given":"Kasper","family":"Dienel","sequence":"first","affiliation":[{"name":"Polymer Technology, School of Chemical Engineering Aalto University  Espoo 02150 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