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In this study, quaternized chitin (QC) derivatives with different degrees of deacetylation (7.4% and 78.9%) are synthesized and their effects on HS formation are evaluated in a rabbit ear scar model. Early application of QC alleviates scar hypertrophy without delayed wound healing. Fibroblast count, collagen content, and <jats:italic>\u03b1<\/jats:italic>\u2010smooth muscle actin expression are decreased, while matrix metalloproteinase\u20101 is upregulated on day 35 in the QC treatment group. QC suppresses inflammatory cell infiltration and IL\u20106 expression. A subsequent reduction in transforming growth factor <jats:italic>\u03b2<\/jats:italic>1 expression is also observed. The inhibitory effect of QC on HS formation is eliminated through the administration of exogenous IL\u20106. Taken together, early application of QC inhibits HS formation by downregulating IL\u20106 expression, and QC with a low degree of deacetylation tends to be more effective. Considering its potential for accelerating wound healing, inhibiting HS formation, and its antibacterial activity, QC may be used as an effective dressing in clinical wound\u00a0management.<\/jats:p>","DOI":"10.1002\/mabi.202100418","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T12:17:31Z","timestamp":1639052251000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Early Application of Quaternized Chitin Derivatives Inhibits Hypertrophic Scar Formation"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4404-4705","authenticated-orcid":false,"given":"Zuhan","family":"Chen","sequence":"first","affiliation":[{"name":"Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan University  Wuhan 430072 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Xie","sequence":"additional","affiliation":[{"name":"Hubei Engineering Center of Natural Polymers\u2010based Medical Materials College of Chemistry &amp; Molecular Sciences Wuhan University  Wuhan 430072 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Xia","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan University  Wuhan 430072 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoen","family":"Bian","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan University  Wuhan 430072 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shichen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan University  Wuhan 430072 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Cai","sequence":"additional","affiliation":[{"name":"Hubei Engineering Center of Natural Polymers\u2010based Medical Materials College of Chemistry &amp; Molecular Sciences Wuhan University  Wuhan 430072 China"},{"name":"Research Institute of Shenzhen Wuhan University  Shenzhen 518057 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan University  Wuhan 430072 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,19]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2008.07.016"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e3182374452"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31406-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41038-019-0175-y"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.04.005"},{"key":"e_1_2_9_6_1","first-page":"D3826","volume":"9","author":"O'Brien L.","year":"2013","journal-title":"Cochrane Database Syst. 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