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A combination of chemotherapy and photothermal therapy (PTT) is reported here to achieve the goal of cascade multistage cancer treatment. A thermally responsive amphiphilic copolymer is designed and then a CuS nanoparticles (NPs)\u2010based carbon monoxide (CO) photoinduced release system and doxorubicin (Dox) are encapsulated to construct the nanomedicine. The large\u2010sized nanomedicine can accumulate in tumors after long circulation in vivo and will generate heat to act as a photothermal therapeutic agent by near infrared (NIR) light. Moreover, synergically release of CO and Dox is achieved and acted as a sensitized chemotherapeutic agent. The combination of PTT and chemotherapy sensitization can effectively eliminate active tumor cells in the periphery of the tumor. CuS NPs are also released after the degradation of nanomedicine and small\u2010sized CuS NPs possess better tumor penetration and achieve penetration\u2010enhanced PTT by further NIR irradiation, thereby effectively eliminating tumor cells inside solid tumors. Hence, cascade multistage cancer treatment of \u201ccombined PTT and chemotherapy sensitization\u201d\u2014\u201cpenetration\u2010enhanced PTT\u201d is achieved, and tumor cells are comprehensively and effectively eliminated.<\/jats:p>","DOI":"10.1002\/mabi.202100429","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T15:11:55Z","timestamp":1639581115000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cascade Tumor Therapy Platform for Sensitized Chemotherapy and Penetration Enhanced Photothermal Therapy"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6473-0123","authenticated-orcid":false,"given":"Sen","family":"Liu","sequence":"first","affiliation":[{"name":"Jiangsu Provincial Engineering Research Center for Biomedical Materials and Advanced Medical Devices Faculty of Mechanical and Material Engineering Huaiyin Institute of Technology  Huaian 223003 China"},{"name":"Institute of Materials Engineering Collaborative Innovation Center of Chemistry for Life Sciences College of Engineering and Applied Sciences Nanjing University  Nanjing Jiangsu 210093 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Shen","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Engineering Research Center for Biomedical Materials and Advanced Medical Devices Faculty of Mechanical and Material Engineering Huaiyin Institute of Technology  Huaian 223003 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongsheng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Engineering Research Center for Biomedical Materials and Advanced Medical Devices Faculty of Mechanical and Material Engineering Huaiyin Institute of Technology  Huaian 223003 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