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In the present study, a hyaluronic acid (HA)\u2010coated chitosan (CS) nanoparticle (HCP) delivery system is fabricated for insulin oral delivery. It is hypothesized that the developed nanoparticles will protect insulin from digestive degradation, promote intestinal epithelial cell absorption, and exert strong in vivo hyperglycemic ability.\u00a0Nanoparticles formulated by CS and sodium tripolyphosphate (TPP) are optimized to form the core nanoparticles (CNPs). HA is further applied to coat CNP (HCP) to improve stability, reduce enzymatic degradation, and promote absorption of insulin.\u00a0HCP promotes insulin uptake by Caco\u20102 cells, absorbs less mucin, and improves intestinal absorption.\u00a0Moreover, an in vivo test demonstrates that oral administration of insulin\u2010loaded HCP exerts strong and continuous hyperthermia effect (with a pharmacological availability (PA) of 13.8%).\u00a0In summary, HCP is a promising delivery platform for insulin oral administration in terms of protecting insulin during digestion, facilitating its absorption and ultimately promoting its oral bioavailability.<\/jats:p>","DOI":"10.1002\/mabi.202100493","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T10:48:59Z","timestamp":1645267739000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Hyaluronic\u2010Acid\u2010Coated Chitosan Nanoparticles for Insulin Oral Delivery: Fabrication, Characterization, and Hypoglycemic Ability"],"prefix":"10.1002","volume":"22","author":[{"given":"Haishan","family":"Wu","sequence":"first","affiliation":[{"name":"School of Food and Biological Engineering Hefei University of Technology  Hefei 230009 China"},{"name":"Engineering Research Center of Bio\u2010Process Ministry of Education Hefei University of Technology  Hefei 230009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering Hefei University of Technology  Hefei 230009 China"},{"name":"Engineering Research Center of Bio\u2010Process Ministry of Education Hefei University of Technology  Hefei 230009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Nan","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering Hefei University of Technology  Hefei 230009 China"},{"name":"Engineering Research Center of Bio\u2010Process Ministry of Education Hefei University of Technology  Hefei 230009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering Hefei University of Technology  Hefei 230009 China"},{"name":"Engineering Research Center of Bio\u2010Process Ministry of Education Hefei University of Technology  Hefei 230009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangfu","family":"Liao","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Nano\u2010Geomaterials of Ministry of Education China University of Geosciences  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jin","family":"Park","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Biotechnology Korea University  Seoul 02841 South of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8814-8672","authenticated-orcid":false,"given":"Jinglei","family":"Li","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering Hefei University of Technology  Hefei 230009 China"},{"name":"Engineering Research Center of Bio\u2010Process Ministry of Education Hefei University of Technology  Hefei 230009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.12.036"},{"key":"e_1_2_9_2_1","first-page":"15","volume":"4","author":"Madhav M.","year":"2011","journal-title":"Asian J. 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