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The key problem in bone tissue engineering that is not completely resolved is the repair of critical large\u2010scale bone and cartilage defects. The chirality of the extracellular matrix plays a decisive role in the physiological activity of bone cells and the occurrence of bone tissue, but the mechanism of chirality in regulating cell adhesion and growth is still in the early stage of exploration. The application progress of chirality\u2010induced bionic scaffolds is reviewed here in bone defects repair based on \u201csoft\u201d and \u201chard\u201d scaffolds. The aim is to summarize the effects of different chiral structures (<jats:sc>l<\/jats:sc>\u2010shaped and<jats:sc>d<\/jats:sc>\u2010shaped) in the process of inducing bionic scaffolds in bone defects repair. In addition, many technologies and methods as well as issues worthy of special consideration for preparing chirality\u2010induced bionic scaffolds are also introduced. It is expected that this work can provide inspiring ideas for designing new chirality\u2010induced bionic scaffolds and promote the development of chirality in bone tissue engineering.<\/jats:p>","DOI":"10.1002\/mabi.202100502","type":"journal-article","created":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T07:40:39Z","timestamp":1646466039000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Chirality\u2010Induced Bionic Scaffolds in Bone Defects Repair\u2014A Review"],"prefix":"10.1002","volume":"22","author":[{"given":"Xinyue","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Chemistry School of Science Tianjin University Tianjin 300354 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery Tianjin Hospital Tianjin 300211 P. R. 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