{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:48:06Z","timestamp":1788187686677,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1608255"],"award-info":[{"award-number":["U1608255"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Biomedical materials with effective hemostatic properties are in great demand in clinical and battlefield application for severe hemorrhage\u00a0control. In this study, nearly amorphous chitin is obtained by treating\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010chitin with superfine grinding, and the solubility of chitin in hexafluoro\u20102\u2010propanol (HFIP) is significantly increased. Chitin and gelatin mixtures are prepared by adding different amount of gelatin to the 8\u00a0mg mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    chitin solution. In the presence water (nonsolvent), the mixtures are gelled as HFIP is replaced by water, and chitin\/gelatin composite sponges with directional pore structure are prepared by directional freeze drying of the hydrogel.\u00a0The structure, porosity, liquid absorbing capacity, biodegradability, and hemostatic properties of the sponges with different ratios of gelatin are investigated.\u00a0The results show that the sponge with the mass ratio of chitin\/gelatin of 1:1 is potential hemostatic material with high absorbing capacity, hemocompatibility, and the best hemostatic performance. The in vivo study demonstrates that hemostatic time of the composite sponge (73 s) is much shorter than of that of gauze (193 s), chitin sponge (132 s) as well as gelatin sponge (116 s) in rat femoral artery injury model.\n                  <\/jats:p>","DOI":"10.1002\/mabi.202200020","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T00:00:01Z","timestamp":1651276801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Hemostatic Performance of \u0251\u2010Chitin\/Gelatin Composite Sponges with Directional Pore Structure"],"prefix":"10.1002","volume":"22","author":[{"given":"Kai","family":"Kang","sequence":"first","affiliation":[{"name":"Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences  Shenyang 110016 China"},{"name":"School of Materials science and Engineering University of Science and Technology of China  Hefei Anhui 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