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Antibacterial and anti\u2010inflammatory materials are also required for wound healing applications, especially in diabetic patients with chronic wounds. In this work, hyaluronic acid (HA) hydrogels with triple activity: antimicrobial, immunomodulatory, and miRNA delivery agent, are presented. It is demonstrated that polyarginine with a degree of polymerization of 30 (PAR30), which is previously shown to have a prolonged antibacterial activity, decreases inflammatory response of lipopolysaccharide\u2010stimulated macrophages. In addition, PAR30 accelerates fibroblast migration in macrophage\/fibroblast coculture system, suggesting a positive effect on wound healing. Furthermore, PAR30 allows to load miRNA into HA hydrogels, and then to deliver them into the cells. To the authors knowledge, this study is the first describing miRNA\u2010loaded hydrogels with antibacterial effect and anti\u2010inflammatory features. Such system can become a tool for the treatment of infected wounds, e.g., diabetic ulcers, as well as for foreign body response modulation.<\/jats:p>","DOI":"10.1002\/mabi.202200043","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T08:41:04Z","timestamp":1648197664000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Polyarginine as a Simultaneous Antimicrobial, Immunomodulatory, and miRNA Delivery Agent within Polyanionic Hydrogel"],"prefix":"10.1002","volume":"22","author":[{"given":"Varvara","family":"Gribova","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale INSERM UMR_S 1121 Biomaterials and Bioengineering  Centre de Recherche en Biom\u00e9decine de Strasbourg, 1 rue Eug\u00e8ne Boeckel Strasbourg 67000 France"},{"name":"Facult\u00e9 de Chirurgie Dentaire Universit\u00e9 de Strasbourg  8 rue Sainte Elisabeth 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