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Herein, a high\u2010strength porous polyetheretherketone scaffold (ps\u2010PK) loaded with antibacterial drug\u2010loaded hydrogel strategy is proposed. The prepared ps\u2010PK possesses high porosity (30.8\u201364.7%) and the compression modulus is between 0.4 and 0.98\u00a0GPa. The interconnected pore\u2010type structure endows it with a drug loading capacity. Poly(<jats:sub>D,L<\/jats:sub>\u2010lactic acid\u2010<jats:italic>co<\/jats:italic>\u2010glycolic acid)\u2010<jats:italic>b<\/jats:italic>\u2010Poly(ethylene glycol)\u2010<jats:italic>b<\/jats:italic>\u2010Poly(<jats:sub>D,L<\/jats:sub>\u2010lactic acid\u2010<jats:italic>co<\/jats:italic>\u2010glycolic acid) (PLGA\u2010PEG\u2010PLGA)\u00a0thermoresponsive hydrogels loaded with vancomycin are used as the drug sustained\u2010release system. The vancomycin\u2010loaded hydrogels in the solution state at a low temperature are filled into a porous polyetheretherketone scaffold (ps\u2010PK\u2010VGel) and formed a gel state after implantation in vivo. The antibacterial rate of ps\u2010PK\u2010VGel against methicillin\u2010resistant staphylococcus aureus in vitro is 99.7% and histological observation in vivo demonstrates that the ps\u2010PK\u2010VGel shows obvious antibacterial activity. Given its excellent antibacterial ability and mechanical properties, the porous PEEK scaffold composite drug\u2010loaded thermosensitive hydrogel has great potential in bone repair surgery applications.<\/jats:p>","DOI":"10.1002\/mabi.202200114","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T23:19:40Z","timestamp":1658186380000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Application of Porous Polyetheretherketone Scaffold\/Vancomycin\u2010Loaded Thermosensitive Hydrogel Composites for Antibacterial Therapy in Bone Repair"],"prefix":"10.1002","volume":"22","author":[{"given":"Desheng","family":"Qi","sequence":"first","affiliation":[{"name":"Engineering Research Center of Special Engineering Plastics, Ministry of Education, College of Chemistry Jilin University  Changchun 130021 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