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However, PEEK exhibits poor osseointegration and low endothelial compatibility. This study demonstrates the phototethering of collagen onto PEEK surfaces to facilitate osteoblastic and vascular endothelial performance. In particular, collagen with methacryloyl groups is covalently tethered to the PEEK surface via surface\u2010initiated photopolymerization. This process is simpler than the conventional method of collagen\u2010tethering and can be extended to the surface\u2010patterning treatment of collagen. The collagen is confirmed to be tethered to the PEEK surface using attenuated total reflection Fourier transform infrared measurements, bicinchoninic acid assays, and atomic force microscopic observations. When human bone marrow\u2010derived mesenchymal stem cells (HbmMSCs) are cultured on collagen\u2010tethered PEEK (COL\u2010PEEK) surfaces, the cells favorably adhere and proliferate. After inducing osteogenic differentiation, the cells on the COL\u2010PEEK surfaces show higher expression levels of osteoblast\u2010related genes and mineralization than those on the PEEK surface. Moreover, the tethering of collagen greatly improves endothelial proliferation. The COL\u2010PEEK surfaces promotes endothelial networking in coculture with HbmMSCs. These results suggest that COL\u2010PEEK is highly compatible with both osteoblasts and vascular endothelial cells. COL\u2010PEEK is a promising implant that induces osteogenesis and angiogenesis to repair bone tissues.<\/jats:p>","DOI":"10.1002\/mabi.202200115","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T06:05:22Z","timestamp":1653285922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Phototethering of Collagen onto Polyetheretherketone Surfaces to Enhance Osteoblastic and Endothelial Performance"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8133-4189","authenticated-orcid":false,"given":"Yoshinori","family":"Arisaka","sequence":"first","affiliation":[{"name":"Department of Organic Biomaterials Institute of Biomaterials and Bioengineering Tokyo Medical and Dental University (TMDU)  2\u20103\u201010 Kanda\u2010Surugadai Chiyoda Tokyo 101\u20100062 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8132-5733","authenticated-orcid":false,"given":"Hiroki","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University (TMDU)  1\u20105\u201045 Yushima Bunkyo Tokyo 113\u20108549 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Yoda","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University (TMDU)  1\u20105\u201045 Yushima Bunkyo Tokyo 113\u20108549 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5212-1371","authenticated-orcid":false,"given":"Nobuhiko","family":"Yui","sequence":"additional","affiliation":[{"name":"Department of Organic Biomaterials Institute of Biomaterials and Bioengineering Tokyo Medical and Dental University (TMDU)  2\u20103\u201010 Kanda\u2010Surugadai Chiyoda Tokyo 101\u20100062 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.endonu.2016.08.005"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-015-0286-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4236\/abb.2014.54035"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-799X-9-18"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mser.2014.10.001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(97)00146-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199201000-00014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbw016"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(99)00312-3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1460-8566"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pen.760250808"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pc.750080202"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2016.12.012"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(01)00300-3"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1383(17)30655-1"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compstruct.2014.12.061"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8020240"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2013.08.030"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12122858"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201900271"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-016-5731-4"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.07.013"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33570"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2015.07.017"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.11.018"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2017.00068"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13132081"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13233-018-6018-z"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c14752"},{"key":"e_1_2_9_30_1","first-page":"36","volume":"4","author":"Kyomoto M.","year":"2014","journal-title":"Reconstr. 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