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While a controlled release over 265 days is achieved for 15% w\/v hydrogels in the previous study, the material shows high stability over 500 days despite having cleavable ester linkages between the PEG macromonomers and their functionalities. In this study, the hydrolyzable ester linkers in the PEG\u2010norbornene precursor structure are exchanged to reduce the degradation time. To this end, 3,6\u2010epoxy\u20101,2,3,6\u2010tetrahydrophthalimide, phenyl carbamate, carbonate ester, and phenyl carbonate ester are introduced as degradable functional groups. Oscillatory shear experiments reveal that they are not affected the in situ gelation. All hydrogel types have gel points of less than 20 s even at a low polymer concentration of 5% w\/v. Hydrogels with varying polymer concentrations have similar mesh sizes, all of which fell in the range of 4\u201312\u00a0nm. The inclusion of phenyl carbonate ester accelerates degradation considerably, with complete dissolution of 15% w\/v hydrogels after 302 days of incubation in \nphosphate buffer (pH 7.4). Controlled release of 150\u00a0kDa fluorescein isothiocyanate\u2010dextran over a period of at least 150 days is achieved with 15% w\/v hydrogels.<\/jats:p>","DOI":"10.1002\/mabi.202200226","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T11:03:21Z","timestamp":1663326201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Investigation of the Impact of Hydrolytically Cleavable Groups on the Stability of Poly(ethylene glycol) Based Hydrogels Cross\u2010Linked via the Inverse Electron Demand Diels\u2013Alder (iEDDA) Reaction"],"prefix":"10.1002","volume":"22","author":[{"given":"Christian E.","family":"Ziegler","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology Faculty of Chemistry and Pharmacy University of Regensburg  93040 Regensburg 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