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Current treatments are based on implanting grafts, which are shown to have several inconveniences. In this regard, tissue engineering through the 3D bioprinting technique has arisen to manufacture structures that would be a feasible therapeutic option for bone regenerative medicine. In this study, nanocellulose\u2013alginate (NC\u2013Alg)\u2010based bioink is improved by adding two different inorganic components such as hydroxyapatite (HAP) and graphene oxide (GO). First, ink rheological properties and biocompatibility are evaluated as well as the influence of the sterilization process on them. Then, scaffolds are characterized. Finally, biological studies of embedded murine D1 mesenchymal stem cells engineered to secrete erythropoietin are performed. Results show that the addition of both HAP and GO prevents NC\u2013Alg ink from viscosity lost in the sterilization process. However, GO is reduced due to short cycle autoclave sterilization, making it incompatible with this ink. In addition, HAP and GO have different influences on scaffold architecture and surface as well as in swelling capacity. Scaffolds mechanics, as well as cell viability and functionality, are promoted by both elements addition. Additionally, GO demonstrates an enhanced bone differentiation capacity.<\/jats:p>","DOI":"10.1002\/mabi.202200236","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T18:38:01Z","timestamp":1660847881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["3D Bioprinted Hydroxyapatite or Graphene Oxide Containing Nanocellulose\u2010Based Scaffolds for Bone Regeneration"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7028-2291","authenticated-orcid":false,"given":"Markel","family":"Lafuente\u2010Merchan","sequence":"first","affiliation":[{"name":"NanoBioCel Group Laboratory of Pharmaceutics School of Pharmacy University of the Basque Country (UPV\/EHU).  Paseo de la Universidad 7 Vitoria\u2010Gasteiz 01006 Spain"},{"name":"Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine (CIBER\u2010BBN). 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