{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:11:20Z","timestamp":1780614680339,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Poly (ether\u2010ether\u2010ketone) (PEEK) displays promising potential application in bone tissue repair and orthopedic surgery due to its good biocompatibility and chemical stability. However, the bio\u2010inertness and poor mechanical strength of PEEK greatly limit its application in load\u2010bearing bones. In this study, calcium silicate whiskers (CSws) are synthesized and then compounded with PEEK to fabricate the PEEK\/CSw composites with excellent mechanical properties, biological activity. Compared with PEEK, the PEEK\/CSw composites exhibited higher hydrophilicity and ability to deposit hydroxyapatite on the surface. CSws are evenly dispersed in the PEEK matrix at 10\u00a0wt% content and the mechanical strength of the PEEK\/CSw composite is \u224896.9\u00a0\u00b1\u00a02.4\u00a0MPa, 136.3\u00a0\u00b1\u00a02.4\u00a0MPa, and 266.0\u00a0\u00b1\u00a03.2\u00a0MPa, corresponding to tensile strength, compressive strength, and bending strength, respectively, which is 20%, 18%, and 52% higher than that of pure PEEK. The composites improve the adhesion, proliferation, and osteogenic differentiation of BMSCs. Furthermore, PEEK\/CSw composite remarkably improves bone formation and osteointegration, which has higher bone repair capacity than PEEK. These results demonstrate that the PEEK\/CSw scaffolds display superior abilities to integrate with the host bone and promising potential in the field of load bearing bone repair.<\/jats:p>","DOI":"10.1002\/mabi.202200321","type":"journal-article","created":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T17:58:40Z","timestamp":1662314320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Calcium Silicate Whiskers\u2010Enforced Poly(Ether\u2010Ether\u2010Ketone) Composites with Improved Mechanical Properties and Biological Activities for Bearing Bone Reconstruction"],"prefix":"10.1002","volume":"22","author":[{"given":"Jin","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Biomedical Material and Engineering Center of Hubei Province Wuhan University of Technology  Wuhan 430070 P. R. 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