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The current research article focuses on the development of hydrogel\u2010based wound dressings combining mechanical strength with high exudate absorption capacities using acrylate\u2010endcapped urethane\u2010based precursors (AUPs). AUPs with varying poly(ethylene glycol) backbone molar masses (10 and 20\u00a0kg mol<jats:sup>\u22121<\/jats:sup>) and endcap chemistries are successfully synthesized in toluene, subsequently processed into UV\u2010cured hydrogel sheets and are benchmarked against several commercial wound dressings (Hydrosorb, Kaltostat, and Mepilex Ag). The AUP materials show high gel fractions (&gt;90%) together with strong swelling degrees in water, phosphate buffered saline and simulated wound fluid (12.7\u201319.6\u00a0g g<jats:sup>\u22121<\/jats:sup>), as well as tunable mechanical properties (e.g., Young's modulus: 0.026\u20130.061\u00a0MPa). The AUPs have significantly (<jats:italic>p<\/jats:italic> &lt; 0.05) higher swelling degrees than the tested commercial dressings, while also being mechanically resistant. The elasticity of the synthesized materials leads to an increased resistance against fatigue. The di\u2010 and hexa\u2010acrylated AUPs show excellent in vitro biocompatibility against human foreskin fibroblasts, as evidenced by indirect MTS assays and live\/dead cell assays. In conclusion, the processed AUP materials demonstrate high potential for wound healing application and can even compete with commercially available dressings.<\/jats:p>","DOI":"10.1002\/mabi.202200341","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T06:59:15Z","timestamp":1669013955000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Fine\u2010Tuning the Endcap Chemistry of Acrylated Poly(Ethylene Glycol)\u2010Based Hydrogels for Efficient Burn Wound Exudate Management"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7471-1970","authenticated-orcid":false,"given":"Manon","family":"Minsart","sequence":"first","affiliation":[{"name":"Polymer Chemistry &amp; Biomaterials Research Group Centre of Macromolecular Chemistry Department of Organic and Macromolecular Chemistry Ghent University  Krijgslaan 281, Building S4\u2010bis Ghent 9000 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Deroose","sequence":"additional","affiliation":[{"name":"Polymer Chemistry &amp; Biomaterials Research Group Centre of Macromolecular Chemistry Department of Organic and Macromolecular Chemistry Ghent University  Krijgslaan 281, Building S4\u2010bis Ghent 9000 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5849-3042","authenticated-orcid":false,"given":"Laurens","family":"Parmentier","sequence":"additional","affiliation":[{"name":"Polymer Chemistry &amp; Biomaterials Research Group Centre of Macromolecular Chemistry Department of Organic and Macromolecular Chemistry Ghent University  Krijgslaan 281, Building S4\u2010bis Ghent 9000 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7688-1682","authenticated-orcid":false,"given":"Sandra","family":"Van Vlierberghe","sequence":"additional","affiliation":[{"name":"Polymer Chemistry &amp; Biomaterials Research Group Centre of Macromolecular Chemistry Department of Organic and Macromolecular Chemistry Ghent University  Krijgslaan 281, Building S4\u2010bis Ghent 9000 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4339-8827","authenticated-orcid":false,"given":"Arn","family":"Mignon","sequence":"additional","affiliation":[{"name":"Smart Polymeric Biomaterials Research Group Biomaterials and Tissue Engineering (SIEM) @ Campus Group T Leuven  Andreas Vesaliusstraat 13 Leuven 3000 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5928-7726","authenticated-orcid":false,"given":"Peter","family":"Dubruel","sequence":"additional","affiliation":[{"name":"Polymer Chemistry &amp; Biomaterials Research Group Centre of Macromolecular Chemistry Department of Organic and Macromolecular Chemistry Ghent University  Krijgslaan 281, Building S4\u2010bis Ghent 9000 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.7603\/s40681-015-0022-9"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.08.070"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3tb20795a"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2526-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0145-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/2321-3868.113332"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2016.11.014"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0358.101319"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2015.24.Sup20.S38"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7544.777"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2012.01097.x"},{"key":"e_1_2_8_12_1","unstructured":"W. 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