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Endowing PEEK with biological activity to promote osseointegration would increase its applicability for bone replacement implants. A biomimetic study is performed, inspired by mineralized collagen fiber bundles that contact bone marrow mesenchymal stem cells (BMMSCs) on the native trabecular bone surface. The PEEK surface (P) is first sulfonated with sulfuric acid to form a porous network structure (sP). The surface is then encapsulated with amorphous hydroxyapatite (HA) by magnetron sputtering to form a biomimetic scaffold that resembles mineralized collagen fiber bundles (sPHA). Amorphous HA simulates the composition of osteogenic regions in vivo and exhibits strong biological activity. In vitro results show that more favorable cell adhesion and osteogenic differentiation can be attained with the novelsurface of sPHA than with SP. The results of in vivo experiments show that sPHA exhibits osteoinductive and osteoconductive activity and facilitates bone formation and osseointegration. Therefore, the surface modification strategy can significantly improve the biological activity of PEEK, facilitate effective osseointegration, and inspire further bionic modification of other inert polymers similar to PEEK.<\/jats:p>","DOI":"10.1002\/mabi.202200436","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T04:04:45Z","timestamp":1673237085000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Biomimetic Mineralized Fiber Bundle\u2010Inspired Scaffolding Surface on Polyetheretherketone Implants Promotes Osseointegration"],"prefix":"10.1002","volume":"23","author":[{"given":"He","family":"Xin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases Department of Oral and Maxillofacial Surgery School of Stomatology Fourth Military Medical 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