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However, many diseases such as cancer and inflammation, are accompanied by a long\u2010term increase in ROS. This situation inspires researchers to use ROS\u2010sensitive nanocarriers for a site\u2010specific release of cargo in pathological areas. Polyamino acid materials with good biodegradability, biocompatibility, and regular secondary structure are widely used in the biomedical field. Herein, a new oxidation responsive PEGylated polyamino acid is synthesised for anticancer drug delivery by ring\u2010opening polymerisation of <jats:italic>N<\/jats:italic>\u2010carboxyanhydrides bearing thioether pendants. The obtained block copolymer mPEG\u2010<jats:italic>b<\/jats:italic>\u2010PMLG self\u2010assembles into spherical nanoparticles (NPs) in water with diameter \u224868.3\u00a0nm. NMR measurement demonstrated that the hydrophobic thioether pendants in the NPs can be selectively oxidised to hydrophilic sulfoxide groups by H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, which will lead to the disassociation of NPs. In vitro drug release results indicated that the encapsulated Nile red is selectively released in the trigger of 10\u00a0mM H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> in PBS. Finally, anticancer drug doxorubicin (DOX) is encapsulated to the NPs, and the obtained NPs\/DOX exhibits an improved antitumor efficacy in 4T1 tumour\u2010bearing mice and lower cardiotoxicity than free DOX. These results indicates that the mPEG\u2010<jats:italic>b<\/jats:italic>\u2010PMLG NPs are promising for anticancer drug delivery.<\/jats:p>","DOI":"10.1002\/mabi.202200498","type":"journal-article","created":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T04:59:07Z","timestamp":1673067547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Oxidation Responsive PEGylated Polyamino Acid Bearing Thioether Pendants for Enhanced Anticancer Drug Delivery"],"prefix":"10.1002","volume":"23","author":[{"given":"Yitao","family":"Sun","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering Changchun University of Science and Technology  Changchun 130022 P. R. China"},{"name":"Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P. R. 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