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Reduced graphene oxide (rGO) is expected to meet the requirements because of its ability to scavenge free radicals through electron transfer. Antioxidant hydrogels based on gelatine methacrylate (GM), acrylyl\u2010\u03b2\u2010cyclodextrin (Ac\u2010CD), and rGO functionalized with \u03b2\u2010cyclodextrin (\u03b2\u2010CD) are developed for skull defect regeneration, but the mechanism of how rGO\u2010based hydrogels enhance bone repair remains unclear. In this work, it is confirmed that the GM\/Ac\u2010CD\/rGO hydrogel has good antioxidant capacity, and promotes osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and angiogenesis of human umbilical vein endothelial cells (HUVECs). The rGO\u2010based hydrogel affects ZEB1\/Notch1 to promote tube formation. Furthermore, two\u2010photon laser scanning microscopy is used to observe the ROS in a skull defect. The rGO\u2010based hydrogel promotes type H vessel formation in a skull defect. In conclusion, the hydrogel neutralizes ROS in the vicinity of a skull defect and stimulates ZEB1\/Notch1 to promote the coupling of osteogenesis and angiogenesis, which may be a possible approach for bone regeneration.<\/jats:p>","DOI":"10.1002\/mabi.202200502","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T18:31:41Z","timestamp":1673634701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["ROS Scavenging Graphene\u2010Based Hydrogel Enhances Type H Vessel Formation and Vascularized Bone Regeneration via ZEB1\/Notch1 Mediation"],"prefix":"10.1002","volume":"23","author":[{"given":"Junpeng","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Bone and Joint Surgery the Second Affiliated Hospital of Xi'an Jiaotong University  NO. 157, Xiwu Road Xi'an Shaanxi 710004 P. R. 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