{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:43:58Z","timestamp":1790999038414,"version":"4.1.0"},"reference-count":71,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["202262016"],"award-info":[{"award-number":["202262016"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001969"],"award-info":[{"award-number":["82001969"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>O\u2010carboxymethyl chitosan (CM\u2010chitosan), holds high potential as a valuable biomaterial for nerve guidance conduits (NGCs). However, the lack of explicit bioactivity on neurocytes and poor duration that does not match nerve repair limit the restorative effects. Herein, CM\u2010chitosan\u2010based NGC is designed to induce the reconstruction of damaged peripheral nerves without addition of other activation factors. CM\u2010chitosan possesses excellent performance in vitro for nerve tissue engineering, such as increasing the organization of filamentous actin and the expression of phospho\u2010Akt, and facilitating the cell cycle and migration of Schwann cells. Moreover, CM\u2010chitosan exhibits increased longevity upon cross\u2010linking (C\u2010CM\u2010chitosan) with 1, 4\u2010Butanediol diglycidyl ether, and C\u2010CM\u2010chitosan fibers possess appropriate biocompatibility. In order to imitate the structure of peripheral nerves, multichannel bioactive NGCs are prepared from lumen fillers of oriented C\u2010CM\u2010chitosan fibers and outer warp\u2010knitted chitosan pipeline. Implantation of the C\u2010CM\u2010chitosan NGCs to rats with 10\u2010mm defects of peripheral nerves effectively improve nerve function reconstruction by increasing the sciatic functional index, decreasing the latent periods of heat tingling, enhancing the gastrocnemius muscle, and promoting nerve axon recovery, showing regenerative efficacy similar to that of autograft. The results lay a theoretical foundation for improving the potential high\u2010value applications of CM\u2010chitosan\u2010based bioactive materials in nerve tissue engineering.<\/jats:p>","DOI":"10.1002\/mabi.202300025","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T03:20:40Z","timestamp":1686194440000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Facilitation of Cell Cycle and Cellular Migration of Rat Schwann Cells by O\u2010Carboxymethyl Chitosan to Support Peripheral Nerve Regeneration"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7499-4963","authenticated-orcid":false,"given":"Zhiwen","family":"Jiang","sequence":"first","affiliation":[{"name":"College of Marine Life Sciences Ocean University of China  Qingdao 266003 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Marine Life Sciences Ocean University of China  Qingdao 266003 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenqi","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Marine Life Sciences Ocean University of China  Qingdao 266003 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Xia","sequence":"additional","affiliation":[{"name":"College of Marine Life Sciences Ocean University of China  Qingdao 266003 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Marine Life Sciences Ocean University of China  Qingdao 266003 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Marine Life Sciences Ocean University of China  Qingdao 266003 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory Qilu Hospital (Qingdao) Cheeloo College of Medicine Shandong University  Qingdao 266035 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3125-5092","authenticated-orcid":false,"given":"Baoqin","family":"Han","sequence":"additional","affiliation":[{"name":"College of Marine Life Sciences Ocean University of China  Qingdao 266003 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.08.074"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.04.161"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202202513"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.11.081"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.112634"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-019-6309-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.02.005"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.09.087"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.05.062"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.05.092"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.02.043"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2008.01.057"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.01.078"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2009.0017"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2011.07.013"},{"key":"e_1_2_8_16_1","first-page":"2361","volume":"124","author":"Wang Y.","year":"2011","journal-title":"Chin. Med. J. (Peking)"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12666"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-022-06669-0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.08.153"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12071445"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.11.047"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.06.104"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2011.04.007"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.01.046"},{"key":"e_1_2_8_25_1","first-page":"220","volume":"12","author":"He B.","year":"2019","journal-title":"Int. J. Clin. Exp. Med."},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.117210"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2018.03.023"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.117832"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2007.06.016"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-009-0123-1"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12301"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC02367J"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2012.09.001"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116994"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-018-1602-2"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9BM00783K"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2018.07.002"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.119032"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.08.010"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199612000-00023"},{"key":"e_1_2_8_41_1","first-page":"255","volume":"170","author":"Monte\u2010Raso V. V.","year":"2008","journal-title":"J. Neurosci."},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182a3bfeb"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202200883"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.810676"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/10731190701857777"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-200204000-00013"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110405"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.264441"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.02.024"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-032320-094706"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260727"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22105367"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-52902-2.00005-9"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.09.008"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00437"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1123"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1305656110"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.14-0555"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23892"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42242-020-00115-2"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.02.010"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.02.080"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reactfunctpolym.2021.104846"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.110419"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.05.119"},{"key":"e_1_2_8_66_1","volume":"6","author":"Wang L.","year":"2020","journal-title":"Sci. Adv."},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004180050341"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.06.029"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.03.020"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.01.157"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11122"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.202300025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T07:02:28Z","timestamp":1697439748000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.202300025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,6]]},"references-count":71,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/mabi.202300025"],"URL":"https:\/\/doi.org\/10.1002\/mabi.202300025","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,6]]},"assertion":[{"value":"2023-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2300025"}}