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Inspired by the platelet function and platelet\u2013macrophage interaction, a platelet\u2010anchored polylactic acid\u2010<jats:italic>b<\/jats:italic>\u2010polyethylene glycol\u2010<jats:italic>b<\/jats:italic>\u2010polylactic acid (PLA\u2010PEG\u2010PLA) electrospun dressing is developed for inflammatory modulation and diabetic wounds healing acceleration. PLA\u2010PEG\u2010PLA electrospun meshes encapsulated with thymosin <jats:italic>\u03b2<\/jats:italic>4 (T<jats:italic>\u03b2<\/jats:italic>4) and CaCl<jats:sub>2<\/jats:sub> is fabricated with electrospinning, followed by immersion of electrospun mesh in platelet\u2010rich plasma to firmly anchor the platelets. It is demonstrated that the anchored platelets on electrospun mesh can enhance the initial macrophage recruitment and control the T<jats:italic>\u03b2<\/jats:italic>4 release from electrospun meshes to facilitate the macrophages polarization to the M2 phenotype. The inflammatory regulation promotes the expression of vascular endothelial growth factor and the migration of vascular endothelial cells for angiogenesis, resulting in accelerated diabetic wounds healing. Therefore, this work paved a new way to design platelet\u2010inspired electrospun meshes for inflammation manipulation and diabetic wound healing.<\/jats:p>","DOI":"10.1002\/mabi.202300036","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T09:04:09Z","timestamp":1685610249000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Bioinspired Platelet\u2010Anchored Electrospun Meshes for Tight Inflammation Manipulation and Chronic Diabetic Wound Healing"],"prefix":"10.1002","volume":"23","author":[{"given":"Tianci","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun Jilin 130022 China"},{"name":"School of Applied Chemistry and Engineering University of Science and Technology of China  Hefei Anhui 230026 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