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The ability for an acellular vascular graft to promote endothelial cell (EC) recruitment in the body would be very beneficial. This study investigated epsins as a target since they are involved in internalization of vascular endothelial growth factor receptor 2. Specifically, epsin\u2010mimetic UPI peptides are delivered locally from vascular grafts to block epsin activity and promote endothelialization. The peptide delivery from fibrin coatings allowed for controlled loading and provided a significant improvement in EC attachment, migration, and growth in vitro. The peptides have even more important impacts after grafting into rat abdominal aortae. The peptides prevented graft thrombosis and failure that is observed with a fibrin coating alone. They also modulated the in vivo remodeling. The grafts are able to remodel without the formation of a thick fibrous capsule on the adventitia with the 100\u00a0\u00b5g\u00a0mL<jats:sup>\u22121<\/jats:sup> peptide\u2010loaded condition, and this condition enabled the formation of a functional EC monolayer in the graft lumen after only 1 week. Overall, this study demonstrated that the local delivery of UPI peptides is a promising strategy to improve the performance of vascular grafts.<\/jats:p>","DOI":"10.1002\/mabi.202300073","type":"journal-article","created":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T01:14:45Z","timestamp":1682730885000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Epsin Mimetic UPI Peptide Delivery Strategies to Improve Endothelization of Vascular Grafts"],"prefix":"10.1002","volume":"23","author":[{"given":"Shirin","family":"Changizi","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Florida Institute of Technology  Melbourne FL 32901 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahyar","family":"Sameti","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Florida Institute of Technology  Melbourne FL 32901 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle L.","family":"Bazemore","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Florida Institute of Technology  Melbourne FL 32901 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"Vascular Biology Program Boston Children's Hospital, Harvard Medical School  Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2637-9149","authenticated-orcid":false,"given":"Chris A.","family":"Bashur","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Florida Institute of Technology  Melbourne FL 32901 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,7]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31828124ad"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201701461"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201700001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201800125"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34295"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.07.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111441"},{"key":"e_1_2_9_8_1","first-page":"509","volume":"41","author":"Brown D. 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