{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:57:58Z","timestamp":1793051878503,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:00:00Z","timestamp":1686614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fibrosis of the filtering bleb is one of the main causes of failure after bleb\u2010forming glaucoma surgery. Intraoperative application of mitomycin C (MMC) is the current gold standard to reduce the fibrotic response. However, MMC is cytotoxic and one\u2010time application is often insufficient. A sustained\u2010release drug delivery system (DDS), loaded with MMC, may be less cytotoxic and equally or more effective. Two degradable (polycaprolactone (PCL) and polylactic\u2010co\u2010glycolic acid (PLGA)) MMC\u2010loaded DDSs are developed. Release kinetics are first assessed in vitro followed by rabbit implants in conjunction with the PRESERFLO MicroShunt. As a control, the MicroShunt is implanted with adjunctive use of a MMC solution. Rabbits are euthanized at postoperative day (POD) 28 and 90. The PLGA and PCL DDSs release (on average) 99% and 75% of MMC, respectively. All groups show functioning blebs until POD 90. Rabbits implanted with a DDS show more inflammation with avascular thin\u2010walled blebs when compared to the control. However, collagen is more loosely arranged. The PLGA DDS shows less inflammation, less foreign body response (FBR), and more complete degradation at POD 90 when compared to the PCL DDS. Further optimization with regard to dosage is required to reduce side effects to the conjunctiva.<\/jats:p>","DOI":"10.1002\/mabi.202300075","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T10:33:45Z","timestamp":1685442825000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Degradable Sustained\u2010Release Drug Delivery System for Bleb\u2010Forming Glaucoma Surgery"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6467-0546","authenticated-orcid":false,"given":"Ralph J.S.","family":"van Mechelen","sequence":"first","affiliation":[{"name":"University Eye Clinic Maastricht, Maastricht University Medical Center+ (MUMC+) Maastricht 6202 AZ The Netherlands"},{"name":"School for Mental Health and Neuroscience Maastricht University Maastricht 6229 ER The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarno E.J.","family":"Wolters","sequence":"additional","affiliation":[{"name":"University Eye Clinic Maastricht, Maastricht University Medical Center+ (MUMC+) Maastricht 6202 AZ The Netherlands"},{"name":"School for Mental Health and Neuroscience Maastricht University Maastricht 6229 ER The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Fredrich","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Experimental Vascular Biology, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam UMC A.M. Vree G1\u2010146 Amsterdam 1100 DD Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian J.F.","family":"Bertens","sequence":"additional","affiliation":[{"name":"University Eye Clinic Maastricht, Maastricht University Medical Center+ (MUMC+) Maastricht 6202 AZ The Netherlands"},{"name":"School for Mental Health and Neuroscience Maastricht University Maastricht 6229 ER The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion J.J.","family":"Gijbels","sequence":"additional","affiliation":[{"name":"School for Mental Health and Neuroscience Maastricht University Maastricht 6229 ER The Netherlands"},{"name":"Department of Medical Biochemistry Experimental Vascular Biology, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam UMC A.M. Vree G1\u2010146 Amsterdam 1100 DD Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert P.H.J.","family":"Schenning","sequence":"additional","affiliation":[{"name":"Laboratory of Stimuli\u2010responsive Functional Materials and Devices, Department of Chemical Engineering and Chemistry Technical University of Eindhoven Eindhoven 5600 MB The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Pinchuk","sequence":"additional","affiliation":[{"name":"InnFocus Inc. a Santen company 12415 S.W. 136 Avenue Miami FL 33186 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo G.M.F.","family":"Gorgels","sequence":"additional","affiliation":[{"name":"University Eye Clinic Maastricht, Maastricht University Medical Center+ (MUMC+) Maastricht 6202 AZ The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9406-1426","authenticated-orcid":false,"given":"Henny J.M.","family":"Beckers","sequence":"additional","affiliation":[{"name":"University Eye Clinic Maastricht, Maastricht University Medical Center+ (MUMC+) Maastricht 6202 AZ The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,13]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-002-0621-5"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000729"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_963_19"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2020.05.005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2015.03.021"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2012.01.008"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)72957-5"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(92)31781-6"},{"key":"e_1_2_9_9_1","first-page":"19","volume":"314","author":"Coppens G.","year":"2010","journal-title":"Bull. Soc. Belge Ophtalmol."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-004-0181-9"},{"key":"e_1_2_9_11_1","first-page":"21","volume":"2","author":"Hung P.","year":"2000","journal-title":"Asia Pac. J. Ophthalmol."},{"key":"e_1_2_9_12_1","first-page":"7","volume":"2","author":"Ghoneim E.","year":"2015","journal-title":"J. Clin. Res. Ophthalmol."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.04.008"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2022.108972"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900702"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.11.038"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.126190"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.54525"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c05824"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2018.01.010"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0PY00919A"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7NR03221H"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.04.055"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma12091438"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/00914037.2018.1539990"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde.14.91"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym3031377"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.07.038"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33648"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.11.8.29"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.108.789974"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000287"},{"key":"e_1_2_9_33_1","first-page":"83","volume":"1","author":"Briot T.","year":"2016","journal-title":"Pharm. Technol. Hosp. Pharm."},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4310258"},{"key":"e_1_2_9_35_1","first-page":"449","volume":"39","author":"Crowston J. G.","year":"1998","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2020.05.005"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12097"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181911271"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000001215"},{"key":"e_1_2_9_40_1","first-page":"1945","volume":"9","author":"Al Habash A.","year":"2015","journal-title":"Clin. Ophthalmol."},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.11.004"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.202300075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T07:02:00Z","timestamp":1697439720000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.202300075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,13]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/mabi.202300075"],"URL":"https:\/\/doi.org\/10.1002\/mabi.202300075","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,13]]},"assertion":[{"value":"2023-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2300075"}}