{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:05:29Z","timestamp":1790395529388,"version":"4.1.0"},"reference-count":121,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["CSC202009110089"],"award-info":[{"award-number":["CSC202009110089"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["19\/FFP\/6522"],"award-info":[{"award-number":["19\/FFP\/6522"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Wound infections slow down the healing process and lead to complications such as septicemia, osteomyelitis, and even death. Although traditional methods relying on antibiotics are effective in controlling infection, they have led to the emergence of antibiotic\u2010resistant bacteria. Hydrogels with antimicrobial function become a viable option for reducing bacterial colonization and infection while also accelerating healing processes. Chitosan is extensively developed as antibacterial wound dressings due to its unique biochemical properties and inherent antibacterial activity. In this review, the recent research progress of chitosan\u2010based hydrogels for infected wound treatment, including the fabrication methods, antibacterial mechanisms, antibacterial performance, wound healing efficacy, etc., is summarized. A concise assessment of current limitations and future trends is presented.<\/jats:p>","DOI":"10.1002\/mabi.202300094","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T14:38:47Z","timestamp":1683729527000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Chitosan\u2010Based Hydrogels for Infected Wound Treatment"],"prefix":"10.1002","volume":"23","author":[{"given":"Xiaoyu","family":"Wang","sequence":"first","affiliation":[{"name":"Charles Institute of Dermatology School of Medicine University College Dublin  Dublin D04 V1W8 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rijian","family":"Song","sequence":"additional","affiliation":[{"name":"Charles Institute of Dermatology School of Medicine University College Dublin  Dublin D04 V1W8 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Johnson","sequence":"additional","affiliation":[{"name":"Charles Institute of Dermatology School of Medicine University College Dublin  Dublin D04 V1W8 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigen","family":"A","sequence":"additional","affiliation":[{"name":"Charles Institute of Dermatology School of Medicine University College Dublin  Dublin D04 V1W8 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu 210023 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Centre of Micro\/Nano Manufacturing Technology (MNMT\u2010Dublin) School of Mechanical and Materials Engineering University College Dublin  Dublin D04 KW52 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Lara\u2010S\u00e1ez","sequence":"additional","affiliation":[{"name":"Charles Institute of Dermatology School of Medicine University College Dublin  Dublin D04 V1W8 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[{"name":"Charles Institute of Dermatology School of Medicine University College Dublin  Dublin D04 V1W8 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5053-0611","authenticated-orcid":false,"given":"Wenxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Charles Institute of Dermatology School of Medicine University College Dublin  Dublin D04 V1W8 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3827912"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.10.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00283.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00303.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/157489110790112581"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2011.0333"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509359125"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2280800021989698"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.7603\/s40681-015-0022-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.47738"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.115839"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA13510F"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c04206"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10924-016-0865-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2019.110627"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-819336-5.00001-7"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/md13031133"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13193256"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0141-8130(87)90033-X"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/02652049709006820"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20235889"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/md13085156"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-0263-7_15"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7915.2008.00080.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.11.59"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12111038"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2012.03.013"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(01)00189-2"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.66.1595"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2007.07.497"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00328-8"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(99)00046-0"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-019-6273-3"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(01)00042-4"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-86502009000600007"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24142629"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2012.12.009"},{"key":"e_1_2_8_38_1","volume":"18","author":"Stricker\u2010Krongrad A. H.","year":"2018","journal-title":"Eplasty"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0939-6411(01)00191-6"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2018.10.010"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700527"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2019.10.008"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.4103\/joacp.JOACP_349_15"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.582779"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom8010004"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-017-1645-z"},{"key":"e_1_2_8_47_1","first-page":"373","volume":"17","author":"Sun Z.","year":"2020","journal-title":"Mol. Pharm."},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.07.060"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.0c00314"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-010-4214-2"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5TB01820J"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.9b00570"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-4-236"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1086\/491709"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1088\/2053-1591\/abb154"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2013.11.012"},{"key":"e_1_2_8_57_1","first-page":"3919","volume":"11","author":"Lei J.","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.07.011"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.115110"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.09.013"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2017.05.011"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjnano.9.98"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.05.041"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.25160"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00396-008-1949-0"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202005941"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201400363"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26041077"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202000252"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2019.12.026"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103629"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma12162540"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CS60218D"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1080\/1539445X.2022.2152461"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano6040071"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1080\/10590501.2015.1055161"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/am508094e"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b02955"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/11\/3\/035015"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-01151-5"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2014.08.031"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2016.10.051"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2017.11.003"},{"key":"e_1_2_8_84_1","first-page":"53","volume":"10","author":"Mohandas A.","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2020.111397"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1080\/10601325.2019.1581576"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.04.002"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2008.01.028"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc020051g"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24972-2"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/macromol2030022"},{"key":"e_1_2_8_92_1","first-page":"289","volume":"41","author":"Ai L. F.","year":"2011","journal-title":"China Surfactant Deterg. Cosmet."},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/app10144719"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02830325"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.02.230"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2004.11.004"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2017.08.132"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpe.2019.10.001"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2011.02.006"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.110557"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2003.12.005"},{"key":"e_1_2_8_102_1","first-page":"277","volume":"29","author":"Yuan W.","year":"2007","journal-title":"Chem. Reagents"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2014.05.076"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1080\/00405000.2016.1218594"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2015.12.078"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.117875"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0144-8617(03)00103-6"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma15010014"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.04.180"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.03.044"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2010.02.008"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2012.01.018"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2015.04.013"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.04.049"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116826"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118718"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.1030851"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202112782"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-021-01615-8"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14010022"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115016"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.202300094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T12:11:25Z","timestamp":1741695085000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.202300094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,9]]},"references-count":121,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/mabi.202300094"],"URL":"https:\/\/doi.org\/10.1002\/mabi.202300094","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,9]]},"assertion":[{"value":"2023-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2300094"}}