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Head trauma, tumor resection and other traumas damage it, requiring artificial dura mater for repair. \u00a0However, surgical tears are often unavoidable. To address these issues, the ideal artificial dura mater should have biocompatibility, anti\u2010leakage, and self\u2010healing properties. Herein, this work has used biocompatible polycaprolactone diol as the soft segment and introduced dynamic disulfide bonds into the hard segment, achieving a multifunctional polyurethane (LSPU\u20102), which integrated the above mentioned properties required in surgery.\u00a0In particular, LSPU\u20102 matches the mechanical properties of the dura mater and the biocompatibility tests with neuronal cells demonstrate extremely low cytotoxicity and do not cause any negative skin lesions. In addition, the anti\u2010leakage properties of the LSPU\u20102 are confirmed by the water permeability tester and the 900\u00a0mm H<jats:sub>2<\/jats:sub>O static pressure test with artificial cerebrospinal fluid. Due to the disulfide bond exchange and molecular chain mobility, LSPU\u20102 could be completely self\u2010healed within 115\u00a0min at human body temperature. Thus, LSPU\u20102 comprises one of the most promising potential artificial dura materials, which is essential for the advancement of artificial dura mater and brain surgery.<\/jats:p>","DOI":"10.1002\/mabi.202300111","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T11:04:57Z","timestamp":1684926297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Toward Highly Matching the Dura Mater: A Polyurethane Integrating Biocompatible, Leak\u2010Proof, and Self\u2010Healing Properties"],"prefix":"10.1002","volume":"23","author":[{"given":"Pandi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery the Affiliated Lihuili Hospital of Ningbo University  Ningbo 315040 P. R. 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