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Airway stenting is an easy way to restore the patency of the central airway, but airway stents commonly used in clinical practice can lead to complications such as mucus plugging, bacterial infection, and granulation tissue hyperplasia. Moreover, the non\u2010degradable characteristic makes it requires a second operation to remove, which has the potential to cause tissue damage. In this study, a biodegradable airway stent is fabricated by microinjection molding using the bioelastomer of poly (L\u2010lactide\u2010<jats:italic>co<\/jats:italic>\u2010<jats:italic>\u03b5<\/jats:italic>\u2010caprolactone) as the matrix material. The airway stent has excellent mechanical properties and an appropriate degradation rate. The hydrophilic surface of the airway stent can inhibit mucus plugging. The loading of silver nanoparticles and cisplatin endows the stent with antibacterial and anti\u2010hyperplastic functions. In vitro and in vivo experiments demonstrate that this study provides an antibacterial and anti\u2010hyperplastic biodegradable airway stent with elastic properties to avoid secondary removal operation and reduce complications associated with mucus plugging, bacterial infection, and granulation tissue hyperplasia.<\/jats:p>","DOI":"10.1002\/mabi.202300113","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T13:14:20Z","timestamp":1686921260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Microinjection Molded Biopolymeric Airway Stent with Antibacterial and Anti\u2010Hyperplastic Properties"],"prefix":"10.1002","volume":"23","author":[{"given":"Jiahui","family":"Dong","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering Zhengzhou University  Zhengzhou 450001 China"},{"name":"School of Mechanics and Safety Engineering National Center for International Research of Micro\u2010Nano Molding Technology Zhengzhou University  Zhengzhou 450001 China"},{"name":"Department of Applied Chemistry Osaka University  Suita Osaka 565\u20100871 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology The First Affiliated Hospital of Zhengzhou University  Zhengzhou 450052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8916-5404","authenticated-orcid":false,"given":"Xiaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Mechanics and Safety Engineering National Center for International Research of Micro\u2010Nano Molding Technology Zhengzhou University  Zhengzhou 450001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Mechanics and Safety Engineering National Center for International Research of Micro\u2010Nano Molding Technology Zhengzhou University  Zhengzhou 450001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology The First Affiliated Hospital of Zhengzhou University  Zhengzhou 450052 China"},{"name":"Engineering Technology Research Center for Minimally Invasive Interventional Tumors of Henan Province  Zhengzhou 450052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuedi","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Mechanics and Safety Engineering National Center for International Research of Micro\u2010Nano Molding Technology Zhengzhou University  Zhengzhou 450001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Zhengzhou University  Zhengzhou 450001 China"},{"name":"School of Mechanics and Safety Engineering National Center for International Research of Micro\u2010Nano Molding Technology Zhengzhou University  Zhengzhou 450001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology The First Affiliated Hospital of Zhengzhou University  Zhengzhou 450052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwei","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology The First Affiliated Hospital of Zhengzhou University  Zhengzhou 450052 China"},{"name":"Interventional Institute of Zhengzhou University  Zhengzhou 450052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Uyama","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry Osaka University  Suita Osaka 565\u20100871 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Zhengzhou University  Zhengzhou 450001 China"},{"name":"School of Mechanics and Safety Engineering National Center for International Research of Micro\u2010Nano Molding Technology Zhengzhou University  Zhengzhou 450001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"e_1_2_9_1_1","volume":"81","author":"Kim J. 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