{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:00Z","timestamp":1786978320676,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22031005"],"award-info":[{"award-number":["22031005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51803106"],"award-info":[{"award-number":["51803106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Abdominal wall defect caused by surgical trauma, congenital rupture, or tumor resection may result in hernia formation or even death. Tension\u2010free abdominal wall defect repair by using patches is the gold standard to solve such problems. However, adhesions following patch implantation remain one of the most challenging issues in surgical practice. The development of new kinds of barriers is key to addressing peritoneal adhesions and repairing abdominal wall defects. It is already well recognized that ideal barrier materials need to have good resistance to nonspecific protein adsorption, cell adhesion, and bacterial colonization for preventing the initial development of adhesion. Herein, electrospun poly(4\u2010hydroxybutyrate) (P4HB) membranes infused with perfluorocarbon oil are used as physical barriers. The oil\u2010infused P4HB membranes can greatly prevent protein attachment and reduce blood cell adhesion in vitro. It is further shown that the perfluorocarbon oil\u2010infused P4HB membranes can reduce bacterial colonization. The in vivo study reveals that perfluoro(decahydronaphthalene)\u2010infused P4HB membranes can significantly prevent peritoneal adhesions in the classic abdominal wall defects\u2019 model and accelerate defect repair, as evidenced by gross examination and histological evaluation. This work provides a safe fluorinated lubricant\u2010impregnated P4HB physical barrier to inhibit the formation of postoperative peritoneal adhesions and efficiently repair soft\u2010tissue defects.<\/jats:p>","DOI":"10.1002\/mabi.202300146","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T01:58:56Z","timestamp":1685152736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Multifunctional Fluorinated Lubricant\u2010Infused Poly(4\u2010Hydroxybutyrate) (P4HB) Membranes for Full\u2010Thickness Abdominal Wall Defect Repair"],"prefix":"10.1002","volume":"23","author":[{"given":"Xiuxia","family":"Sun","sequence":"first","affiliation":[{"name":"College of Chemical Engineering Qingdao University of Science and Technology  Qingdao 266042 P. R. 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