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However, it is still a challenge in efficient transdermal drug delivery for psoriasis treatment due to low penetration efficiency of most drugs and the abnormal skin conditions of psoriasis patients. Here, a safe and effective methacryloyl chitosan hydrogel microneedles (CSMA hMNs) patch is developed and served as a sustained drug release platform for the treatment of psoriasis. By systematically optimizing the CSMA preparation, CSMA hMNs with excellent morphological characteristics and strong mechanical properties (0.7 N\u00a0needle\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) are prepared with a concentration of only 3% (w\/v) CSMA. As a proof\u2010of\u2010concept, methotrexate (MTX) and nicotinamide (NIC) are loaded into CSMA hMNs patch, which can produce a sustained drug release of 80% within 24\u00a0h in vitro. In vivo experiments demonstrated that the CSMA hMNs patch can effectively inhibit the skin thickening and spleen enlargement of psoriatic mice and has a good biosafety profile at sufficient therapeutic doses. This study provides a new idea for the preparation of hMN systems using modified CS or other biocompatible materials and offers an effective therapeutic option for psoriasis treatment.\n                  <\/jats:p>","DOI":"10.1002\/mabi.202300194","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T07:49:20Z","timestamp":1691048960000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["A Novel Methacryloyl Chitosan Hydrogel Microneedles Patch with Sustainable Drug Release Property for Effective Treatment of Psoriasis"],"prefix":"10.1002","volume":"23","author":[{"given":"Panpan","family":"Dai","sequence":"first","affiliation":[{"name":"College of Pharmacy China Pharmaceutical University  Nanjing 211198 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Ge","sequence":"additional","affiliation":[{"name":"College of Pharmacy China Pharmaceutical 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Natural Medicine China Pharmaceutical University  Nanjing 211198 China"},{"name":"MOE Joint International Research Laboratory of Animal Health and Food Safety and Laboratory of Animal Bacteriology (Ministry of Agriculture), College of Veterinary Medicine Nanjing Agricultural University  Nanjing 210095 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5158-3846","authenticated-orcid":false,"given":"Yanmin","family":"Ju","sequence":"additional","affiliation":[{"name":"College of Pharmacy China Pharmaceutical University  Nanjing 211198 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