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Although silver has been used strongly in past centuries as an anti\u2010bacterial, it can lead to allergic reactions, bacterial resistance, and delayed wound healing. Iodine\u2010based antibacterials are becoming an interesting alternative. In this work, the effect of complexation with poly(vinyl pyrrolidone) (PVP) and poly(ethylene oxide) (PEO)\u2010based polymers is explored by using different acrylate\u2010endcapped urethane\u2010based poly(ethylene glycol) (AUP) polymers, varying the molar mass (MM) of the poly(ethylene glycol) (PEG) backbone, with possible addition of PVP. The higher MM AUP outperforms the swelling potential of commercial wound dressings such as Kaltostat, Aquacel Ag, and Hydrosorb and all MM show superior mechanical properties. The addition of iodine to the polymers is compared to Iso\u2010Betadine Tulle (IBT). Interestingly, the addition of PVP does not lead to increased iodine complexation compared to the blank AUP polymers, while all have a prolonged iodine release compared to the IBT, which leads to a burst release. The observed prolonged release also leads to larger inhibition zones during antibacterial tests. Complexing iodine in AUP polymers with or without PVP leads to antimicrobial wound dressings which may hold potential for future application to treat infected wounds.<\/jats:p>","DOI":"10.1002\/mabi.202300202","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T17:58:40Z","timestamp":1698861520000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Poly(Vinyl Pyrrolidone) on Iodine Release from Acrylate\u2010Endcapped Urethane\u2010Based Poly(Ethylene Glycol) Hydrogels as Antibacterial Wound Dressing"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4339-8827","authenticated-orcid":false,"given":"Arn","family":"Mignon","sequence":"first","affiliation":[{"name":"Polymer Chemistry and Biomaterials Group Center of Macromolecular Chemistry Department of Organic and Macromolecular Chemistry Ghent University  Krijgslaan 281, S4\u2010bis 9000 Gent Ghent Belgium"},{"name":"Smart Polymeric Biomaterials Biomaterials and Tissue Engineering Campus Group T KU, Leuven  Andreas Vesaliusstraat 13 3000 Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Gheysens","sequence":"additional","affiliation":[{"name":"Polymer Chemistry and Biomaterials Group Center of Macromolecular Chemistry Department of Organic and Macromolecular Chemistry Ghent University  Krijgslaan 281, S4\u2010bis 9000 Gent Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander","family":"Walraet","sequence":"additional","affiliation":[{"name":"Polymer Chemistry and Biomaterials Group Center of Macromolecular Chemistry Department of Organic and Macromolecular Chemistry Ghent University  Krijgslaan 281, S4\u2010bis 9000 Gent Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Tack","sequence":"additional","affiliation":[{"name":"Department of Chemistry Ghent University  Krijgslaan 281, S12 9000 Gent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Rigole","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Microbiology Ghent University  Ottergemsesteenweg 460 Gent 9000 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Coenye","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Microbiology Ghent University  Ottergemsesteenweg 460 Gent 9000 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Vincze","sequence":"additional","affiliation":[{"name":"Department of Chemistry Ghent University  Krijgslaan 281, S12 9000 Gent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Van Vlierberghe","sequence":"additional","affiliation":[{"name":"Polymer Chemistry and Biomaterials Group Center of Macromolecular Chemistry Department of Organic and Macromolecular Chemistry Ghent University  Krijgslaan 281, S4\u2010bis 9000 Gent Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Dubruel","sequence":"additional","affiliation":[{"name":"Polymer Chemistry and Biomaterials Group Center of Macromolecular Chemistry Department of Organic and Macromolecular Chemistry Ghent University  Krijgslaan 281, S4\u2010bis 9000 Gent Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318163cd14"},{"key":"e_1_2_8_2_1","unstructured":"Burns https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/burns(accessed: April 2021)."},{"key":"e_1_2_8_3_1","unstructured":"D. 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Clinical Microbiology Reviews 2023 e00024\u201323.","DOI":"10.1128\/cmr.00024-23"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.38657"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.202300202","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mabi.202300202","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.202300202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:26:24Z","timestamp":1785428784000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.202300202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,14]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/mabi.202300202"],"URL":"https:\/\/doi.org\/10.1002\/mabi.202300202","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,14]]},"assertion":[{"value":"2023-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2300202"}}