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Recently, there has been a great deal of effort to design and develop anticancer biocompatible polymeric nanoplatforms including polypeptide and PEGylated ones to achieve effective ferroptosis therapy (FT) and synergistic combination therapies including chemotherapy (CT), photodynamic therapy (PDT), sonodynamic therapy (SDT), photothermal therapy (PTT), gas therapy (GT) including nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H<jats:sub>2<\/jats:sub>S), and immunotherapy (IT). To be noted, the combo therapies such as FT\u2010CT, FT\u2010PTT, FT\u2010GT, and FT\u2010IT are attracting much efforts to fight against intractable and metastatic tumors as they can generate synergistic antitumor effects and immunogenic cell death (ICD) effects or modulate immunosuppressive tumor microenvironments to initiate strong antitumor immunity and memory effects. The polymeric Fenton nano\u2010agents with good biosafety and high anticancer efficacy will provide a guarantee for their applications. In this review, various biocompatible polymer\u2010modified nanoplatforms designed for FT and combo treatments are summarized for anticancer therapies and discussed for potential clinical transitions.<\/jats:p>","DOI":"10.1002\/mabi.202300215","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T18:04:52Z","timestamp":1687802692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Biocompatible Polymer\u2010Modified Nanoplatform for Ferroptosis\u2010Enhanced Combination Cancer Therapy"],"prefix":"10.1002","volume":"23","author":[{"given":"Meng","family":"He","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules Shanghai Key Laboratory of Electrical Insulation and Thermal Aging Shanghai Jiao Tong University Shanghai 200240 P. R. 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