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Aminosilane layer deposition has previously been shown to control NG108\u201015 neuronal cell and primary Schwann cell adhesion and differentiation by controlling deposition of \u2500NH<jats:sub>2<\/jats:sub> groups at the submicron scale across the entirety of a surface by varying silane chain length. This is the first study toreport depositing 11\u2010aminoundecyltriethoxysilane (CL11) onto aligned Polycaprolactone (PCL) scaffolds for peripheral nerve regeneration. Fibers are manufactured via electrospinning and characterized using water contact angle measurements, atomic force microscopy (AFM), and X\u2010ray photoelectron spectroscopy (XPS). Confirmed modified fibers are investigated using in vitro cell culture of NG108\u201015 neuronal cells and primary Schwann cells to determine cell viability, cell differentiation, and phenotype. CL11\u2010modified fibers significantly support NG108\u201015 neuronal cell and Schwann cell viability. NG108\u201015 neuronal cell differentiation maintains Schwann cell phenotype compared to unmodified PCL fiber scaffolds. 3D ex vivo culture of Dorsal root ganglion explants (DRGs) confirms further Schwann cell migration and longer neurite outgrowth from DRG explants cultured on CL11 fiber scaffolds compared to unmodified scaffolds. Thus, a reproducible and cost\u2010effective tool is reported to modify biomaterials with functional amine groups that can significantly improve nerve guidance devices and enhance nerve regeneration.<\/jats:p>","DOI":"10.1002\/mabi.202300226","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T19:19:04Z","timestamp":1687807144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Aminosilane Functionalized Aligned Fiber PCL Scaffolds for Peripheral Nerve Repair"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9042-9913","authenticated-orcid":false,"given":"Caroline S.","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Materials Science &amp; Engineering, Kroto Research Institute Broad Lane  Sheffield S3 7HQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Barnes","sequence":"additional","affiliation":[{"name":"Department of Mechanical, Materials and Aerospace, School of Engineering University of Liverpool  Harrison Hughes Building Liverpool L69 3GH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3760-8373","authenticated-orcid":false,"given":"Manohar","family":"Prasad Koduri","sequence":"additional","affiliation":[{"name":"Department of Mechanical, Materials and Aerospace, School of Engineering University of Liverpool  Harrison Hughes Building Liverpool L69 3GH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamsal","family":"Haq","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Liverpool  Crown Street Liverpool L69 7ZD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2489-5462","authenticated-orcid":false,"given":"David A.","family":"Gregory","sequence":"additional","affiliation":[{"name":"Department of Materials Science &amp; Engineering, Kroto Research Institute Broad Lane  Sheffield S3 7HQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5602-1714","authenticated-orcid":false,"given":"Ipsita","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Materials Science &amp; Engineering, Kroto Research Institute Broad Lane  Sheffield S3 7HQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2651-8783","authenticated-orcid":false,"given":"Raechelle A.","family":"D'Sa","sequence":"additional","affiliation":[{"name":"Department of Mechanical, Materials and Aerospace, School of Engineering University of Liverpool  Harrison Hughes Building Liverpool L69 3GH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1551-2917","authenticated-orcid":false,"given":"Judith","family":"Curran","sequence":"additional","affiliation":[{"name":"Department of Mechanical, Materials and Aerospace, School of Engineering University of Liverpool  Harrison Hughes Building Liverpool L69 3GH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3950-3583","authenticated-orcid":false,"given":"John W.","family":"Haycock","sequence":"additional","affiliation":[{"name":"Department of Materials Science &amp; Engineering, Kroto Research Institute Broad Lane  Sheffield S3 7HQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,7]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2011.0498"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-011-4263-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2010.12.030"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2011.0438"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.10.025"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.18063\/ijb.v4i1.123","volume":"4","author":"Behbehani M.","year":"2017","journal-title":"Int. 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